2010 Fiscal Year Final Research Report
Possibility of direct hemoper fusion using a new cytokine absorbing column
| Project/Area Number |
20592118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
TANIGUCHI Takumi Kanazawa University, 医学系, 准教授 (30301196)
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| Research Collaborator |
KURITA Akihide 金沢大学, 医学系, 助教 (10507081)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 血液浄化 / サイトカイン / ショック / 多臓器不全 / アシドーシス |
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| Research Abstract |
Our previous study demonstrated that direct hemoperfusion using a new cytokine absorbing column (CTR treatment) reduced mortality and inhibited inflammatory responses in endotoxic-shock rats. The present research was performed to evaluate the effects of CTR treatment on hypercytokinemia induced by acute lung injury and hemorrhagic shock in rats. The present research demonstrated that the CTR treatment had beneficial effects on hypercytokinemia induced by acute lung injury and hemorrhagic shock in rats. These findings suggest that CTR treatment may be effective for the treatment of patients with hypercytokinemia.
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