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2010 Fiscal Year Final Research Report

Role of C/EBPβ, a transcription factor in neutrophils, in the pathogenesis of septic acute lung injury

Research Project

  • PDF
Project/Area Number 20592125
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

SHIME Nobuaki  Kyoto Prefectural University of Medicine, 医学研究科, 講師 (00260795)

Co-Investigator(Kenkyū-buntansha) HIRAI Hideyo  京都大学, 医学研究科, 助教 (50315933)
Project Period (FY) 2008 – 2010
Keywords集中治療医学
Research Abstract

The purpose of this study is to obtain basic data for maintaining proper body weight by controlling obesity following childbirth. The levels of autonomic nerve activity and body composition were measured in pregnant and puerperal women by analyzing the power spectra of heat rate fluctuations. Results 1) Parasympathetic nerve activity decreased while sympathetic nerve activity increased in the third trimester as compared with the second trimester. 2) Increased body fat percentage, decreased muscle volume and increased autonomic nerve activity were confirmed following childbirth. The results of this study can be applied to the development of a proper weight management program for use after childbirth by monitoring BMI and body composition starting one year after childbirth.

  • Research Products

    (25 results)

All 2010 2009 2008

All Journal Article (14 results) (of which Peer Reviewed: 13 results) Presentation (10 results) Book (1 results)

  • [Journal Article] Eradication of the commensal intestinal microflora by oral antimicrobials interferes with the host response to lipopolysaccharide.2010

    • Author(s)
      Umenai T, Hirai H, Shime N, Nakaya T, Asahara T, Nomoto K, Kita M, Tanaka Y, Imanishi J.
    • Journal Title

      Eur J Clin Microbiol Infect Dis 29(6)

      Pages: 633-641

    • Peer Reviewed
  • [Journal Article] The importance of a judicious and early empiric choice of antimicrobial for methicillin-resistant Staphylococcus aureus bacteraemia.2010

    • Author(s)
      Shime N, Kosaka T, Fujita N.
    • Journal Title

      Eur J Clin Microbiol Infect Dis 29(12)

      Pages: 1475-1479

    • Peer Reviewed
  • [Journal Article] Use of bicistronic vectors in combination with flow cytometry to screen for effective small interfering RNA target sequences.2010

    • Author(s)
      Kamio N, Hirai H, Ashihara E, Tenen DG, Maekawa T, Imanishi J
    • Journal Title

      Biochem Biophys Res Commun 393

      Pages: 498-503

    • Peer Reviewed
  • [Journal Article] Pharmacokinetics and tolerance of linezolid for meticillin-resistant Staphylococcus aureus mediastinitis in paediatric patients.2009

    • Author(s)
      Kosaka T, Kokufu T, Shime N, Sugioka N, Kato R, Hamaoka K, Fujita N.
    • Journal Title

      Int J Antimicrob Agents 32(12)

      Pages: 368-370

    • Peer Reviewed
  • [Journal Article] Hyperventilation versus standard ventilation for infants in postoperative care for congenital heart defects with pulmonary hypertension.2009

    • Author(s)
      Umenai T, Shime N, Kato Y, Hashimoto S.
    • Journal Title

      J Anesth 23(81)

      Pages: 80-86

    • Peer Reviewed
  • [Journal Article] Clinical and hemodynamic factors associated with the outcome of early extubation attempts after right heart bypass surgery.2009

    • Author(s)
      Kurihara Y, Shime N, Miyazaki T, Kato Y, Hashimoto S.
    • Journal Title

      Interact Cardiovasc Thorac Surg 8(6)

      Pages: 624-628

    • Peer Reviewed
  • [Journal Article] Disseminated Aspergillosis Following Resolution of Pneumocystis Pneumonia with Sustained Elevation of Beta-Glucan in an Intensive Care Unit : a Case Report.2009

    • Author(s)
      Saito T, Shime N, Itoh K, Fujita N, Saito Y, Shinozaki M, Shibuya K, Makimura K, Hashimoto S.
    • Journal Title

      Infection 37(6)

      Pages: 547-550

    • Peer Reviewed
  • [Journal Article] Identification of a myeloid committed progenitor as the cancer initiating cell in acute promyelocytic leukemia.2009

    • Author(s)
      Guibal FC, Alberich-Jorda M, Hirai H, Ebralidze A, Levantini E, Di Ruscio A, Zhang P, Santana-Lemos BA, Neuberg D, Wagers AJ, Rego EM, Tenen DG
    • Journal Title

      Blood 114(27)

      Pages: 5415-5425

    • Peer Reviewed
  • [Journal Article] Toll-like receptors (TLRs) are expressed by myeloid leukaemia cell lines, but fail to trigger differentiation in response to the respective TLR ligands.2009

    • Author(s)
      Okamoto M, Hirai H, Taniguchi K, Shimura K, Inaba T, Shimazaki C, Taniwaki M, Imanishi J
    • Journal Title

      Br J Haematol 147(4)

      Pages: 585-587

    • Peer Reviewed
  • [Journal Article] C/EBPファミリー転写因子による好中球産生の制御機構2009

    • Author(s)
      平位秀世
    • Journal Title

      医学のあゆみTOPICS 23(12)

      Pages: 1199-1200

  • [Journal Article] Fas ligand released by activated monocytes causes apoptosis of lung epithelial cells in human acute lung injury model in vitro.2008

    • Author(s)
      Mizuta M, Nakajima H, Mizuta N, Kitamura Y, Nakajima Y, Hashimoto S, Matsuyama H, Shime N, Amaya F, Koh H, Ishizaka A, Magae J, Tanuma SI, Hashimoto S.
    • Journal Title

      Biol Pharm Bull 31

      Pages: 386-390

    • Peer Reviewed
  • [Journal Article] Current problems in the diagnosis and treatment of hospital-acquired methicillin-resistant Staphylococcus aureus pneumonia.2008

    • Author(s)
      Sakaguchi M, Shime N, Fujitaitae, FujitaaFujiki S, Hashimoto S.
    • Journal Title

      J Anesth. 22(2)

      Pages: 125-130

    • Peer Reviewed
  • [Journal Article] Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.2008

    • Author(s)
      Hashimoto S, Okayama Y, Shime N, Kimura A, Funakoshi Y, Kawabata K, Ishizaka A, Amaya F.
    • Journal Title

      Respirology 13(4)

      Pages: 581-584

    • Peer Reviewed
  • [Journal Article] Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors : an experimental study.2008

    • Author(s)
      Matsuyama H, Amaya F, Hashimoto S, Ueno H, Beppu S, Mizuta M, Shime N, Ishizaka A, Hashimoto S.
    • Journal Title

      Respir Res 9

      Pages: 79

    • Peer Reviewed
  • [Presentation] Candidemia-Induced Emergency Granulopoiesis Consist of Successive Dual Waves Triggered by the Shift from C/EBPalpha Dependency to C/EBPbeta Dependency.2010

    • Author(s)
      佐竹早紀子, 平位秀世, 志馬伸朗, 長尾里奈, 田中瑠璃子, 八尾尚幸, 林嘉宏, 稲葉亨, 藤田直久, 今西二郎, 前川平
    • Organizer
      52st ASH ANNUAL MEETING AND EXPOSITION
    • Place of Presentation
      ORLAND
    • Year and Date
      2010-12-06
  • [Presentation] 敗血症による2相性"緊急"好中球造血のフローサイトメトリーによる解析2010

    • Author(s)
      佐竹早紀子, 平位秀世, 志馬伸朗, 長尾里奈, 田中瑠璃子, 八尾尚幸, 林嘉宏, 武内美紀, 芦原英司, 稲葉亨, 藤田直久,今西二郎, 前川平
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
  • [Presentation] 「骨髄系細胞の分化と機能制御」「緊急」顆粒球造血時のC/EBPβの制御におけるCREBファミリー転写因子2010

    • Author(s)
      Hirai H, Kamio N, Matsusue A, Ogino S, Kimura N, Satake S, Tanaka R, Nagao R, Yao H, Hayashi Y, Takeuchi M, Ashihara E, Huang G, Tenen DG, Imanishi J, Maekawa T
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
  • [Presentation] 敗血症時の好中球造血における転写因子の機能解析2010

    • Author(s)
      佐竹早紀子, 平位秀世, 志馬伸朗, 芦原英司, 稲葉亨, 藤田直久, 今西二郎, 前川平
    • Organizer
      第84回日本感染症学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-06
  • [Presentation] Performance of evidence-based preventive measures for ventilator-associated pneumonia in Japanese healthcare settings.2010

    • Author(s)
      Shime N, Satake S, Hosokawa K, Hashimoto S
    • Organizer
      The 10th. joint scientific congress of the Korean society of critical care medicine and Japanese society of intensive care medicine.
    • Place of Presentation
      Hiroshima
    • Year and Date
      2010-03-06
  • [Presentation] CREB Is Involved in the Regulation of C/EBPβ During 'emergency' Granulopoiesis.2009

    • Author(s)
      Hirai H, Kamio N, Matsusue A, Ogino S, Kimura N, Satake S, Ashihara E, Maekawa T, Tenen DG, Imanishi J
    • Organizer
      The American Society of Hematology 51st Annual Meeting and Exposition
    • Place of Presentation
      New Orleans
    • Year and Date
      2009-12-05
  • [Presentation] Involvement of CREB in the regulation of "emergency" granulopoiesis through upregulation of C/EBP Kyoto University Global COE Center for Frontier Medicine2009

    • Author(s)
      平位秀世
    • Organizer
      International Symposium/Retreat2009.
    • Place of Presentation
      Hyogo
    • Year and Date
      2009-11-07
  • [Presentation] Sweep of the intestinal microflora induced by oral administration of antibiotics impairs host response to LPS through down-regulation of the surface Toll-like receptors expressions on the peritoneal macrophages.2009

    • Author(s)
      Umenai T, Hirai H, Nakaya T, Nakaya T, Tanaka Y, Imanishi J
    • Organizer
      The 49th. Interscience Conference on Antimicrobial Agents and Chemotherapy.
    • Place of Presentation
      San Francisco
    • Year and Date
      2009-09-12
  • [Presentation] Ventilator-associated pneumonia.2009

    • Author(s)
      志馬伸朗
    • Organizer
      The 9th. joint scientific congress of the Korean society of critical care medicine and Japanese society of intensive care medicine
    • Place of Presentation
      Seoul
    • Year and Date
      2009-04-25
  • [Presentation] フローサイトメーターを用いた敗血症における顆粒球造血過程の検討2009

    • Author(s)
      藤木早紀子, 平位秀世, 志馬伸朗, 稲葉亨, 藤田直久, 今西二郎
    • Organizer
      第83回日本感染症学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-24
  • [Book] 人工呼吸器関連肺炎のすべて2010

    • Author(s)
      志馬伸朗(編著)
    • Publisher
      東京:南江堂

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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