2010 Fiscal Year Final Research Report
Evaluation of immune regulation against oral commensal bacteria and its impact on host protection against infection.
| Project/Area Number |
20592137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
ISODA Ryutaro Osaka University, 大学院・歯学研究科, 特任研究員 (40456942)
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| Co-Investigator(Kenkyū-buntansha) |
KAWABATA Shigetada 大阪大学, 大学院・歯学研究科, 教授 (50273694)
TERAO Yutaka 大阪大学, 大学院・歯学研究科, 准教授 (50397717)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 口腔細菌学 / 歯周炎 / 動物モデル / 常在細菌 / 粘膜免疫 / 免疫寛容 / 歯周病原性細菌 |
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| Research Abstract |
We tried to establish a new mouse model of human periodontal disease. The new model is based on the hypothesis that periodontal disease might be caused by commensal bacteria under certain conditions rather than by transient infection of foreign pathogens.
The method we used exposed the fetal mouse to human periodontopathic bacteria before other environmental bacteria are incorporated to the commensal bacterial flora of the new born mice.
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