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2010 Fiscal Year Final Research Report

Intranuclear action of Cell cycle-specific growth inhibitory factor, CDT

Research Project

  • PDF
Project/Area Number 20592140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionHiroshima University

Principal Investigator

SUGAI Motoyuki  Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (10201568)

Project Period (FY) 2008 – 2010
Keywords口腔細菌 / CDT / 細胞死 / 細胞周期 / 歯周病 / Aggregatibactor actinomycetemcomitans
Research Abstract

When CdtB was expressed in yeat, Cdt acted as cytolethal and inhibited cell cycle at S/G2. Effect of mutation of DNA repair system on CDT-induced cell death was studied. Mutants of ead51, mre11, rad50 and wrs2 were found to be highly sensitive to CdtB. Further effect of mutation of apoptotic pathway on CDT-induced cell death was studied. Mutants of yca1 and aif1 did not change their susceptibility to CdtB. These resuts suggest that Cdt-induced yeast cell death is not dependent on apoptosis.

  • Research Products

    (5 results)

All 2011 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (1 results)

  • [Journal Article] Topical application of Aggregatibacter actinomycetemcomitans CDT induces cell cycle arrest in the rat gingival epithelium in vivo.2011

    • Author(s)
      Masaru Ohara, Mutsumi Miyauchi, Keiko Tsuruda, Takashi Takata, Motoyuki Sugai.
    • Journal Title

      Journal of Periodontal Research 46

      Pages: 389-395

    • Peer Reviewed
  • [Journal Article] Cytolethal distending toxin from Aggregatibacter actinomycetemcomitans induces DNA damage, S/G2 cell cycle arrest and caspase-independent death in budding yeast model.2010

    • Author(s)
      Oranart Matangkasombut, Roongtiwa Wattanawaraporn, Keiko Tsuruda, Masaru Ohara, Motoyuki Sugai, Skorn Mongkolsuk.
    • Journal Title

      Infection and Immunity 78

      Pages: 783-792

    • Peer Reviewed
  • [Journal Article] Cytolethal distending toxin type I and type IV genes are framed with lambdoid prophage genes in extraintestinal pathogenic Escherichia coli.2009

    • Author(s)
      Toth I, Nougayrede JP, Dobrindt U, Ledger TN, Boury M, Morabito S, Fujiwara T, Sugai M, Hacker J, Oswald E.
    • Journal Title

      Infection and Immunity 77(1)

      Pages: 492-500

    • Peer Reviewed
  • [Journal Article] Cytolethal distending toxin induces caspase-dependent and -independent cell death in MOLT-4 and Jurkat cells.2008

    • Author(s)
      Ohara, M., Hayashi, T., Kusunoki, Y., Nakachi, K., Fujiwara, T., Komatsuzawa, H., Sugai, M.
    • Journal Title

      Infection and Immunity 76(10)

      Pages: 4783-4791

    • Peer Reviewed
  • [Presentation] Cytolethal distending toxin from Aggregatibacter actinomycetemcomitans induces DNA damage, S/G2 cell cycle arrest and caspase-independent death in budding yeast model.2009

    • Author(s)
      Matangkasombut, O., Wattanawaraporn, R., Tsuruda, K., Ohara, M., Sugai, M., Mongkolsuk, S.
    • Organizer
      3^<rd> Hiroshima Conference on Education and Science in Dentistry
    • Place of Presentation
      Hiroshima
    • Year and Date
      20091107-20091108

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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