Effect of PACAP on saliva secretion.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592148
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Showa University
• Principal Investigator: NONAKA Naoko 昭和大学, 歯学部, 講師 (20307052)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Masanori 昭和大学, 歯学部, 教授 (50180394) ; SHIODA Seiji 昭和大学, 医学部, 教授 (80102375) ; NAKAMACHI Tomoya 昭和大学, 遺伝子組換え実験室, 助教 (30433840)
• Project Period (FY): 2008 – 2010
• Keywords: ドライマウス / 唾液腺 / PACAP

Research Abstract

The control of saliva secretion is mainly under the autonomic nervous control. Pituitary adenylate cyclase-activating polypeptide(PACAP) is now recognized as the multi-functional neuropeptide in various organs. We compared the distribution of PACAP and its receptor, PAC-1, in major salivary glands ; parotid, submandibular and sublingual glands, of young(8 weeks) and old(8 months) C57BL/6 mice.

Research Products

• [Journal Article] Distribution of neuropeptide W in the rat brain (2010)
  • Author(s): Takenoya F, Yagi M, Kageyama H, Shiba K, Endo K, Nonaka N, Date Y, Nakazato M, Shioda S
  • Journal Title: Neuropeptids Volume: 44 Pages: 99-106
• [Presentation] Immunohistochemical localizations of pituitary adenylate cyclase-activating polypeptide(PACAP) and its receptor(PAC1R) in mouse major salivary glands (2011)
  • Author(s): Naoko Nonaka, Tomoya Nakamachi, Seiji Shioda, Masanori Nakamura
  • Organizer: 第10回日中合同組織細胞化学セミナー
  • Place of Presentation: 北京
  • Year and Date: 20111000
• [Presentation] マウス唾液腺におけるPACAPレセプターの局在とPACAPの唾液分泌への効果 (2011)
  • Author(s): 野中直子, 中村雅典
  • Organizer: 第53回歯科基礎医学会学術大会抄録集,第53回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 岐阜
  • Year and Date: 20110900
• [Presentation] マウス唾液腺におけるPACAPレセプターおよびVIPレセプターの免疫組織化学的局在と唾液分泌への効果 (2011)
  • Author(s): 野中直子, 中町智哉, 塩田清二, 中村雅典
  • Organizer: 第52回日本組織細胞化学会総会・学術集会予稿集,第52回日本組織細胞化学会
  • Place of Presentation: 金沢
  • Year and Date: 20110900
• [Presentation] マウス唾液腺におけるPACAPレセプターの局在とPACAP経鼻投与による唾液分泌量の亢進 (2011)
  • Author(s): 野中直子, 中町智哉, 塩田清二, 中村雅典
  • Organizer: 第11回日本抗加齢学会総会抄録集,第11回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 20110500
• [Presentation] Immunohistochemical localization of pituitary adenylate cyclase-activating polypeptide(PACAP) and its receptor(PAC-1) in mouse major salivary glands (2011)
  • Author(s): Naoko Nonaka, Tomoya Nakamachi, Seiji Shioda, Masanori Nakamura
  • Organizer: AAA Annual Meeting at Experimental Biology 2011
  • Place of Presentation: Washington DC
  • Year and Date: 20110400
• [Presentation] Immunohistochemical comparison of the localization of PACAP and its receptor, PAC-1, in major salivary glands between young and old mice (2011)
  • Author(s): Naoko Nonaka, Tomoya Nakamachi, Seiji Shioda, Masanori Nakamura
  • Organizer: The Journal of Physiological Sciences Volume61, Supplement 1, 2011 S223, The 116^<th> Annual meeting of the Japanese Association of Anatomists
  • Place of Presentation: Yokohama
  • Year and Date: 20110300
• [Presentation] マウスおよびヒト唾液腺におけるPACAPとPAC1Rの免疫組織化学的局在 (2011)
  • Author(s): 野中直子, 中村雅典
  • Organizer: 第65回日本人類学会大会抄録集,第65回日本人類学会大会
  • Place of Presentation: 沖縄
  • Year and Date: 20110000