2010 Fiscal Year Final Research Report
Molecular biological analysis of periodontopathic biofilm formation and its restraints by functional proteins
| Project/Area Number |
20592150
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
KATO Tetsuo Tokyo Dental College, 歯学部, 教授 (00159253)
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| Co-Investigator(Kenkyū-buntansha) |
KIMIZUKA Ryuta 東京歯科大学, 歯学部, 講師 (90287178)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 細菌 / 歯学 / 歯周病 / バイオフィルム / 機能性タンパク質 |
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| Research Abstract |
Dental plaque, a microbial biofilm formed by multiple organisms tightly adhered to the tooth surface, plays a key role in the development of periodontal disease. The effect of functional proteins on the periodontopathic biofilm formation was determined using the flat bottom of 96-well cell culture plates. Cystatin significantly inhibited biofilm formation by some periodontopathic bacterial strains. Galectins markedly suppressed IL-6 induction in human umbilical vascular endothelial cells by periodontopathic bacterial endotoxin.
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