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2010 Fiscal Year Final Research Report

Elucidation of the disease molecules in oral lichen planus using proteome analysis.

Research Project

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Project/Area Number 20592155
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionNihon University

Principal Investigator

KOMIYAMA Kazuo  Nihon University, 歯学部, 教授 (00120452)

Co-Investigator(Renkei-kenkyūsha) ESUMI Mariko  日本大学, 医学部, 准教授 (30167291)
ABIKO Munemitu  日本大学, 松戸歯学部, 教授 (70050086)
MUKAE Shotaro  日本大学, 歯学部, 専修医 (70553105)
Project Period (FY) 2008 – 2010
Keywords口腔扁平苔癬 / プロテオーム解析 / Cytokeratin 13 / Cytokeratin 17
Research Abstract

To clarify the disease status of an intractable lesion of oral mucosa, such as oral lichen planus, we have employed the LC-MS/MS analysis. 92 proteins of specific for the oral lichen planus have detected. The data compared with epithelial dysplasia, carcinoma in situ and carcinoma of oral mucosa. We have found different expression pattern of cytokeratins, which is decreased CK13 expression in the oral lichen planus and carcinoma in situ as well as disappearance in the invasive carcinoma. However, CK17 expression increased in a course of progression of the epithelial dysplasia and atypia. This contradict expression pattern of CK is usefulness for the differential diagnosis in these malignant borderline lesions.

  • Research Products

    (16 results)

All 2011 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (10 results) Book (1 results) Remarks (1 results)

  • [Journal Article] 【病理形態学キーワード】頭頸部 白斑と白板2010

    • Author(s)
      小宮山一雄
    • Journal Title

      病理と臨床 Vol.28臨時増刊号

      Pages: 18-19

  • [Journal Article] Detection of fascin and CCR7 positive mature dendritic cells in oral lichen planus.2009

    • Author(s)
      Mukae S, Okazaki Y, Tsuda H, Nagai K, Matsumoto N, Ochiai T, Oki H, Komiyama K
    • Journal Title

      J Oral Path & Med. Vol.38, No.4

      Pages: 334-342

    • Peer Reviewed
  • [Journal Article] 口腔粘膜遅延型アレルギー反応における成熟型樹枝状細胞の検出2009

    • Author(s)
      迎章太郎,岡崎泰尋,津田宏尚,金子泰英,澤田昭仁,長井幸一,荒井秀次,落合豊子,小宮山一雄
    • Journal Title

      日大歯学 Vol.83, No.1

      Pages: 13-18

    • Peer Reviewed
  • [Journal Article] 【口腔粘膜病変の臨床と病理】口腔扁平苔癬と苔癬様口内炎2008

    • Author(s)
      小宮山一雄,落合豊子
    • Journal Title

      病理と臨床 Vol.26, No.6

      Pages: 573-583

  • [Presentation] 口腔がん境界病変の臨床像と病理組織像 早期診断・治療のために2011

    • Author(s)
      小宮山一雄
    • Organizer
      東京都歯科医師会講習会
    • Place of Presentation
      東京都
    • Year and Date
      20110100
  • [Presentation] Differential Proteomics defined Keratin-13 and -17 in oral malignancy.2010

    • Author(s)
      Kazuo Komiyama, Naoyuki Matsumoto, Koichi Nagai, Hidero Oki
    • Organizer
      10^<th> Biennial Conference of EAOM Incorporating The World Workshop on Oral Medicine.
    • Place of Presentation
      United Kingdom
    • Year and Date
      2010-09-21
  • [Presentation] Application of proteomics analysis of formalin fixed paraffin embedded oral lichen planus tissue.2010

    • Author(s)
      Kazuo Komiyama, Naoyuki Matsumoto, Shotaro Mukae, Mariko Esumi
    • Organizer
      15^<th> International congress on Oral Pathology and Medicine, 73^<rd> Annual Meeting Korean Academy of Oral & Maxillofacial Pathology.
    • Place of Presentation
      Korea
    • Year and Date
      2010-08-16
  • [Presentation] LC-MS/MSによる口腔粘膜腫瘍性病変のタンパク質プロファイルの解析2010

    • Author(s)
      長井幸一,松本直行,西村叔枝,澤田昭仁,小宮山一雄
    • Organizer
      第99回日本病理学会総会・学術大会
    • Place of Presentation
      京王プラザホテル,東京
    • Year and Date
      2010-04-27
  • [Presentation] Histopathological feature of oral lichen planus.2009

    • Author(s)
      小宮山一雄
    • Organizer
      20th Annual Meeting of the Japanese Society of Oral Pathology.
    • Place of Presentation
      ロイトン札幌,北海道
    • Year and Date
      2009-08-01
  • [Presentation] 口腔扁平苔癬として経過観察中に扁平上皮癌の発生をみた3例2009

    • Author(s)
      山下雅子、神部芳則、伊藤弘人、野口忠秀、草間幹夫、松本直行、小宮山一雄
    • Organizer
      第19回日本口腔粘膜学会学術大会
    • Place of Presentation
      ロフォス湘南,神奈川
    • Year and Date
      2009-06-05
  • [Presentation] 口腔粘膜遅延型過敏症モデルマウスにおける樹枝状細胞の検出2009

    • Author(s)
      迎章太郎,荒井秀次,大木秀郎,小宮山一雄
    • Organizer
      第63回日本口腔科学会学術集会
    • Place of Presentation
      アクトシティ浜松,静岡県
    • Year and Date
      2009-04-16
  • [Presentation] Histopathological Diagno sis of Borderline Malignancy of the Oral Mucosa.2009

    • Author(s)
      小宮山一雄
    • Organizer
      Interactive Seminar on Oral Mucosal Lesion
    • Place of Presentation
      Gothenburg University, Sweden
    • Year and Date
      2009-03-24
  • [Presentation] Oral lichen planus病巣におけるmature dendritic cellの検出2008

    • Author(s)
      迎章太郎,松本直行,齋藤康行,神部芳則,大木秀郎,米原啓介,草間幹夫,小宮山一雄
    • Organizer
      第18回日本口腔粘膜学会総会・学術集会
    • Place of Presentation
      日本大学会館,東京都
    • Year and Date
      2008-09-19
  • [Presentation] プロテオーム解析を利用した口腔粘膜癌境界病変の分子診断マーカーの検討2008

    • Author(s)
      松本直行、迎章太郎、天野雄介、尾曲大輔、荒井秀次、大久保光朗、齋藤康行、大場育弘、生木俊輔、西村敏、田中孝佳、石井輝彦、岩成進吉、三宅正彦、清水治、米原啓之、大木秀郎、小宮山一雄
    • Organizer
      第60回日本大学歯学会
    • Place of Presentation
      日本大学歯学部,東京都
    • Year and Date
      2008-05-17
  • [Book] Supplement of 20^<th> Annual Meeting of the Japanese Society of Oral Pathology(Approaches to Correct Diagnosis of the Oral Lichen Planus-Concept of Clinical Status and Histopathology-)2009

    • Author(s)
      Komiyama K, Maeda H
    • Total Pages
      1-49
    • Publisher
      International Academic Printing Co. Ltd.
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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