2010 Fiscal Year Final Research Report
Microenvironment of stem cells in bone formation
| Project/Area Number |
20592163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
NINOMIYA Tadashi Matsumoto Dental University, 総合歯科医学研究所, 講師 (00360222)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hiroaki 松本歯科大学, 歯学部, 教授 (50227930)
HIRAGA Toru 松本歯科大学, 歯学部, 准教授 (70322170)
KOIDE Masanori 松本歯科大学, 総合歯科医学研究所, 講師 (10367617)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 硬組織形成 / Side Population細胞 / 歯根膜細胞 / 微小環境 |
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| Research Abstract |
To elucidate the micro environment of stem cell in alveolar bone formation, we examined osteogenic potential of side population (SP) cell which contain abundantly the stem cells, in PDL cells. Isolated SP cells from rat PDL cells had high potential in differentiation into osteoblasts and formation of calcified matrices, compared with non-SP (NSP) cells. The gene expressions of osteoblast markers and BMP-2 in SP cells were higher level than that in NSP cells. On the other hand, the gene expressions of mineralization inhibitors such as periodontal ligament-associated protein-1 were high level in NSP cells. This study indicates that SP cells in PDL have high abilities to form bone-like matrices and are effective in regeneration of alveolar bone.
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[Journal Article] Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo.2011
Author(s)
T.Yonezawa, S.Hasegawa, M.Asai, T.Ninomiya, T.Sasaki, BY Cha, T.Teruya, H.Ozawa, K.Yagasaki, K.Nagai, JT.Woo
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Journal Title
Eur J Pharmcol 650
Pages: 511-518
Peer Reviewed
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[Journal Article] Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling.2009
Author(s)
M.Koide, S.Kinugawa, T.Ninomiya, T.Mizoguchi, T.Yamashita, K.Maeda, H.Yasuda, Y.Kobayashi, H.Nakamura, N.Takahashi, N.Udagawa
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Journal Title
J Bone Miner Res 24
Pages: 1469-1480
Peer Reviewed
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[Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.2009
Author(s)
T.Mizoguchi, N.Muto, N.Udagawa, A.Arai, T.Yamashita, A.Hosoya, T.Ninomiya, H.Nakamura, Y.Yamamoto, A.Kinugawa, M.Nakamura, Y.Nakamishi, Y.Kobayashi, S.Nagasawa, K.Oda, H.Tanaka, M.Tagaya, JM.Penninger, M.Ito, N.Takahashi
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Journal Title
J Cell Biol 184
Pages: 541-554
Peer Reviewed
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[Journal Article] Alveolar bone regeneration of subcutaneously transplanted rat molar.2008
Author(s)
A.Hosoya, T.Ninomiya, T.Hiraga, C.Zhao, K.Yoshiba, N.Yoshiba, M.Takahashi, T.Okabe, S.Wakitani, H.Yamada, E.Kasahara, H.Ozawa, H.Nakamura
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Peer Reviewed
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