2010 Fiscal Year Final Research Report
Roles of the claudin family of tight junction molecules in epithelial lumenformation of the submandibular gland
| Project/Area Number |
20592167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
HIEDA Yohki Osaka Dental University, 歯学部, 准教授 (30243132)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Yoshiya 大阪歯科大学, 歯学部, 助教 (20228430)
KAWAI Shinjiro 大阪歯科大学, 歯学部, 教授 (70131381)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 唾液腺 / 管腔形成 / タイトジャンクション / 極性 / アピカル / 転写因子 |
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| Research Abstract |
In this study, we investigated roles of claudins and gene expression profile in epithelial tube formation of the mouse submandibular gland. We tried to reveal the role of claudin-10 in tube formation of cultured glands by means of siRNAs, however, no clear results indicating the involvement of tube formation were obtained. In addition to the 8 members of the claudin family, claudin-15 was expressed in the mouse submandibular gland. We also identified apical membrane proteins and transcription factors that were up-regulated during tube formation. These molecules will give us clues to understanding mechanisms of epithelial tube formation.
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