2010 Fiscal Year Final Research Report
Induction mechanism of oral dryness by the sialogogue pilocarpine
| Project/Area Number |
20592178
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
INENAGA Kiyotoshi Kyushu Dental College, 歯学部, 教授 (90131903)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Kentro 九州歯科大学, 歯学部, 助教 (40316154)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ピロカルピン / セビメリン / 唾液分泌 / 口渇 / 昇圧 |
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| Research Abstract |
Pilocarpine and cevimeline induce salivary secretion and get wet in the oral cavity. We showed that intraperitoneally and intracerebroventricularly injected pilocarpine elicited water intake in rats and the induced behavior was suppressed by intracerebroventricularly preadministered atropine. The same applications of pilocarpine increased the number of c-Fos positive neurons in the subfornical organ, median nucleus of preoptic area, and organum vasculosum of lamina terminalis, which may constitute the thirst center in the brain. Pilocarpine directly affected and depolarized neurons in the subfornical organ of slice preparations. On the other hand, intraperitoneally injected cevimeline did not increase water intake but rather suppressed angiotensin II-induced water intake. Pilocarpine and cevimeline increased intracellular calcium concentration in acinar cells of the salivary gland in vitro preparations. The increment of intracellular calcium concentration with in vitro application was rather short-lasting than with in vivo application. Thus, pilocarpine and cevimeline show actions on acinar cells of the salivary gland through the same intracellular second messenger system. From these results, it is suggested that pilocarpine and cevimeline have different actions between the central nervous system and the peripheral organs.
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[Presentation] ラット耳下腺細胞のコリン性・アドレナリン性刺激による多様な反応
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[Presentation] ラットにおける中枢コリン性アゴニスト刺激による口の渇き誘発作用
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[Presentation] 脳弓下器官におけるニコチン受容体と口腔機能
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[Presentation] ラット耳下腺細胞に対するピロカルピンおよびセビメリンの作用
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[Presentation] 飲水行動のアセチルコリン制御
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[Presentation] Nicotinic reception in rat subfornical organ neurons and glial cells
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[Presentation] Mechanism of drinking behavior by central activation of nicotinic receptor in rat
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[Presentation] ラット耳下腺細胞における催唾剤により細胞内カルシウム濃度上昇
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[Presentation] Effects of pilocarpine and cevimeline on Ca^<2+> mobilization in rat parotid acini and ducts
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[Presentation] Ca^<2+> mobilization by nicotine through synaptic activation in rat parotid acini
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[Presentation] Mechanism of drinking induced by the sialogogue pilocarpine in rats
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[Presentation] のどの渇きとアセチルコリン
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[Presentation] ニコチンによるラット耳下腺腺房細胞の細胞内Ca^<2+>動態
