2010 Fiscal Year Final Research Report
Development of novel drugs to control oral biofilms towards clinical application
| Project/Area Number |
20592181
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
KATO Hirohisa Iwate Medical University, 歯学部, 教授 (60152740)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Yasuo 愛知学院大学, 歯学部, 准教授 (10315096)
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| Project Period (FY) |
2008 – 2010
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| Keywords | バイオフィルム / 酵素 / う蝕 / 歯周病 |
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| Research Abstract |
The Shiitake extracts inhibited the biofilm formation of Streptococcus mutans in dose dependent manner. By contrast, the extracts did not affect the growth of the planktonic bacterial cells. It was suggested that the effective components are produced in time dependent manner. In addition, it was elucidated that the enzymatic activity of S. mutans glycosyltransferases was inhibited by the Shiitake extracts. These results revealed the possibility that the effective materials from Shiitake and related species might be clinically available as drugs to reduce dental caries.
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