Mechanism of neural circuits in the gustatory cortex

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20592188
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Nihon University
• Principal Investigator: KOBAYASHI Masayuki Nihon University, 歯学部, 准教授 (00300830)
• Project Period (FY): 2008 – 2011
• Keywords: 神経科学 / 生理学 / 解剖学 / 薬理学 / 歯学

Research Abstract

ホールセル・パッチクランプ法ならびに免疫組織化学的手法を用いることによって,(1)島皮質がどのような神経回路によって構築されているのか明らかにするとともに,(2)その機能的な特徴を解明することによって,味覚情報処理機構の特殊性を浮き彫りにする。

Research Products

• [Journal Article] Functional mapping of gustatory neurons in the insular cortex revealed by pERK-immunohistochemistry and in vivo optical imaging (2010)
  • Author(s): Kobayashi M, Fujita S, Takei H, Song L, Chen S, Suzuki I, Yoshida A, Iwata K, Koshikawa N
  • Journal Title: Synapse 64 Pages: 323-334
• [Journal Article] Spatiotemporal dynamics of excitation in rat insular cortex: intrinsic cortico-cortical circuit regulates caudal-rostro excitatory propagation from the insular to frontal cortex. (2010)
  • Author(s): Fujita S, Adachi K, Koshikawa N, Kobayashi M
  • Journal Title: Neuroscience 165 Pages: 278-292
• [Journal Article] Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex (2010)
  • Author(s): Chen S, Fujita S, Koshikawa N, Kobayashi M
  • Journal Title: Neuroscience 166 Pages: 341-353
• [Journal Article] Assessment of jaw movements by magnetic sensor in relation to topographies of orofacial behaviour in freely moving rats: Studies with the dopamine D(1)-like receptor agonists SKF 83822 vs SKF 83959 (2010)
  • Author(s): Fujita S, Kiguchi M, Kobayashi M, Kinsella A, Koshikawa N, Waddington JL
  • Journal Title: Eur J Pharmacol 632 Pages: 39-44
• [Journal Article] Involvement of NMDA receptors in the ventrolateral striatum of rats in apomorphine-induced jaw movements (2010)
  • Author(s): Fujita S, Kiguchi M, Kobayashi M, Koshikawa N, Waddington JL
  • Journal Title: Brain Res 1322 Pages: 30-37
• [Journal Article] Orofacial movements in phospholipase C-related catalytically inactive protein (PRIP)-1/2 double knockout mice: effect of the GABAergic agent diazepam and the D1 dopamine receptor agonist SKF 83959 (2010)
  • Author(s): Tomiyama K, Song L, Kobayashi M, Kinsella A, Kanematsu T, Hirata M, Koshikawa N, Waddington JL
  • Journal Title: Synapse 64 Pages: 714-720
• [Journal Article] Presynaptic interneuron subtype- and age-dependent modulation of GABAergic synaptic transmission by β-adrenoceptors in rat insular cortex (2010)
  • Author(s): Koyanagi Y, Yamamoto K, Oi Y, Koshikawa N, Kobayashi M
  • Journal Title: J Neurophysiol 103 Pages: 2876-2888
• [Journal Article] Postsynaptic cell type-dependent cholinergic regulation of GABAergic synaptic transmission in rat insular cortex. (2010)
  • Author(s): Yamamoto K, Koyanagi Y, Koshikawa N, Kobayashi M
  • Journal Title: J Neurophysiol 104 Pages: 1933-1945
• [Journal Article] Insulin facilitates repetitive spike firing in rat insular cortex via phosphoinositide 3-kinase but not mitogen activated protein kinase cascade (2010)
  • Author(s): Takei H, Fujita S, Shirakawa T, Koshikawa N, Kobayashi M
  • Journal Title: Neuroscience 170 Pages: 1199-1208
• [Presentation] 島皮質における興奮伝達の長期増強 (2010)
  • Author(s): 小林真之, 藤田智史, 越川憲明
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: 松戸
  • Year and Date: 20100900
• [Presentation] Pilocarpine-induced status epilepticus causes hyper-excitatory propagation and interneuron loss in rat agranular insular cortex. Nov (2010)
  • Author(s): Fujita S, Chen S, Mizoguchi N, Koshikawa K, Kobayashi M
  • Organizer: 40th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego
  • Year and Date: 20100000
• [Presentation] β-Adrenoceptors differentially regulate inhibitory synaptic transmission depending on presynaptic interneuron subtype in rat cerebral cortex. Nov (2010)
  • Author(s): Koyanagi Y, Oi Y, Koshikawa K, Kobayashi M
  • Organizer: 40th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego
  • Year and Date: 20100000
• [Presentation] Postsynaptic cell type-dependent cholinergic regulation of GABAergic synaptic transmission in rat insular cortex. Nov (2010)
  • Author(s): Yamamoto K, Koshikawa K, Kobayashi M
  • Organizer: 40th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego
  • Year and Date: 20100000
• [Presentation] 側頭葉てんかんモデル動物における島皮質の抑制性ニューロンの脱落と興奮伝播の促進 (2009)
  • Author(s): 小林真之, 越川憲明
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 20090900