Mechanism of neural circuits in the gustatory cortex

2011 Fiscal Year Final Research Report

• Project/Area Number: 20592188
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Nihon University
• Principal Investigator: KOBAYASHI Masayuki 日本大学, 歯学部, 准教授 (00300830)
• Research Collaborator: BUCKMASTER Paul 米国スタンフォード大学, 医学部, 准教授
• Project Period (FY): 2008 – 2011
• Keywords: 神経科学 / 生理学 / 解剖学 / 薬理学 / 歯学

Research Abstract

The present study demonstrated the spatial distribution patterns of GABAergic neurons in rat insular cortex. In addition, the neural mechanisms of local circuits of the insular cortex, which consists of excitatory and inhibitory neurons, were explored, and the effects of agonists of adrenergic β-, muscarinic, and GABA_B receptors were examined by multiple whole-cell patch-clamp recording.

Research Products

• [Journal Article] Disruption of programmed masticatory movements in unilateral MPTP-treated monkeys as a model of jaw movement abnormality in Parkinson's disease (2012)
  • Author(s): Adachi K, Kobayashi M, Kawasaki T, Yokoyama C, Waddington JL, Sakagami H, Onoe H, Koshikawa N
  • Journal Title: J Neural Transmission Volume: (in press)
  • Peer Reviewed
• [Journal Article] Histaminergic effects on the frequency of repetitive spike firing in rat insular cortex (2012)
  • Author(s): Takei H, Song L, Ebihara K, Shirakawa T, Koshikawa N, Kobayashi M
  • Journal Title: Neurosci Lett Volume: (in press)
  • Peer Reviewed
• [Journal Article] Spatiotemporal profiles of transcallosal connections in rat insular cortex revealed by in vivo optical imaging (2012)
  • Author(s): Fujita S, Kitayama T, Mizoguchi N, Oi Y, Koshikawa N, Kobayashi M
  • Journal Title: Neuroscience Volume: 206 Pages: 201-211
  • Peer Reviewed
• [Journal Article] Kinetics of GABA_B autoreceptor-mediated suppression of GABA release in rat insular cortex (2012)
  • Author(s): Kobayashi M, Takei H, Yamamoto K, Hatanaka H, Koshikawa N
  • Journal Title: J Neurophysiol Volume: 107 Pages: 1431-1442
  • Peer Reviewed
• [Journal Article] D_2-like dopamine receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell (2012)
  • Author(s): Kohnomi S, Koshikawa N, Kobayashi M
  • Journal Title: J Neurophysiol Volume: 107 Pages: 692-703
  • Peer Reviewed
• [Journal Article] Gustatory imagery reveals functional connectivity from the prefrontal to insular cortices traced with magnetoencephalography (2011)
  • Author(s): Kobayashi M, Sasabe T, Shigihara Y, Tanaka M, Watanabe Y
  • Journal Title: PLoS ONE Volume: 6 Pages: e21736
  • Peer Reviewed
• [Journal Article] Spatiotemporal dynamics of long-term potentiation in rat insular cortex revealed by optical imaging (2011)
  • Author(s): Mizoguchi N, Fujita S, Koshikawa N, Kobayashi M
  • Journal Title: Neurobiol Learn Mem Volume: 96 Pages: 468-478
  • Peer Reviewed
• [Journal Article] GABA_B receptors accentuate neural excitation contrast in rat insular cortex (2011)
  • Author(s): Fujita S, Koshikawa N, Kobayashi M
  • Journal Title: Neuroscience Volume: 199 Pages: 259-271
  • Peer Reviewed
• [Journal Article] Functional mapping of gustatory neurons in the insular cortex revealed by pERK-immunohistochemistry and in vivo optical imaging (2010)
  • Author(s): Kobayashi M, Fujita S, Takei H, Song L, Chen S, Suzuki I, Yoshida A, Iwata K, Koshikawa N
  • Journal Title: Synapse Volume: 64 Pages: 323-334
  • Peer Reviewed
• [Journal Article] Spatiotemporal dynamics of excitation in rat insular cortex : intrinsic cortico-cortical circuit regulates caudal-rostro excitatory propagation from the insular to frontal cortex (2010)
  • Author(s): Fujita S, Adachi K, Koshikawa N, Kobayashi M
  • Journal Title: Neuroscience Volume: 165 Pages: 278-292
  • Peer Reviewed
• [Journal Article] Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex (2010)
  • Author(s): Chen S, Fujita S, Koshikawa N, Kobayashi M
  • Journal Title: Neuroscience Volume: 166 Pages: 341-353
  • Peer Reviewed
• [Journal Article] Assessment of jaw movements by magnetic sensor in relation to topographies of orofacial behaviour in freely moving rats : Studies with the dopamine D(1)-like receptor agonists SKF 83822 vs SKF 83959 (2010)
  • Author(s): Fujita S, Kiguchi M, Kobayashi M, Kinsella A, Koshikawa N, Waddington JL
  • Journal Title: Eur J Pharmacol Volume: 632 Pages: 39-44
  • Peer Reviewed
• [Journal Article] Involvement of NMDA receptors in the ventrolateral striatum of rats in apomorphine-induced jaw movements (2010)
  • Author(s): Fujita S, Kiguchi M, Kobayashi M, Koshikawa N, Waddington JL
  • Journal Title: Brain Res Volume: 1322 Pages: 30-37
  • Peer Reviewed
• [Journal Article] Orofacial movements in phospholipase C-related catalytically inactive protein(PRIP)-1/2 double knockout mice : effect of the GABAergic agent diazepam and the D1 dopamine receptor agonist SKF 83959 (2010)
  • Author(s): Tomiyama K, Song L, Kobayashi M, Kinsella A, Kanematsu T, Hirata M, Koshikawa N, Waddington JL
  • Journal Title: Synapse Volume: 64 Pages: 714-720
  • Peer Reviewed
• [Journal Article] Postsynaptic cell type-dependent cholinergic regulation of GABAergic synaptic transmission in rat insular cortex (2010)
  • Author(s): Yamamoto K, Koyanagi Y, Koshikawa N, Kobayashi M
  • Journal Title: J Neurophysiol Volume: 104 Pages: 1933-1945
  • Peer Reviewed
• [Journal Article] Presynaptic interneuron subtype-and age-dependent modulation of GABAergic synaptic transmission by β-adrenoceptors in rat insular cortex (2010)
  • Author(s): Koyanagi Y, Yamamoto K, Oi Y, Koshikawa N, Kobayashi M
  • Journal Title: J Neurophysiol Volume: 103 Pages: 2876-2888
  • Peer Reviewed
• [Journal Article] Insulin facilitates repetitive spike firing in rat insular cortex via phosphoinositide 3-kinase but not mitogen activated protein kinase cascade (2010)
  • Author(s): Takei H, Fujita S, Shirakawa T, Koshikawa N, Kobayashi M
  • Journal Title: Neuroscience Volume: 170 Pages: 1199-1208
  • Peer Reviewed
• [Journal Article] Pre-and postsynaptic modulation of glutamatergic synaptic transmission by activation ofα_1- and β-adrenoceptors in layer V pyramidal neurons of rat cerebral cortex (2009)
  • Author(s): Kobayashi M, Kojima M, Koyanagi Y, Adachi K, Imamura K, Koshikawa N
  • Journal Title: Synapse Volume: 63 Pages: 269-281
  • Peer Reviewed
• [Journal Article] Activation of α_1-adrenoceptors increases firing frequency through protein kinase C in pyramidal neurons of rat visual cortex (2008)
  • Author(s): Kobayashi M, Sasabe T, Shiohama Y, Koshikawa N
  • Journal Title: Neurosci Lett Volume: 430 Pages: 175-180
  • Peer Reviewed
• [Journal Article] Developmental profile of GABA_A-mediated synaptic transmission in pyramidal cells of the somatosensory cortex (2008)
  • Author(s): Kobayashi M, Hamada T, Kogo M, Yanagawa Y, Obata K, Kang Y
  • Journal Title: Eur J Neurosci Volume: 28 Pages: 849-861
  • Peer Reviewed
• [Presentation] Responses of insular cortical neurons to orofacial noxious stimulation (2012)
  • Author(s): Adachi K, Beppu Y, Koshikawa N, Sakagami H, Shimada J, Kobayashi M
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都国際会議場,京都
  • Year and Date: 2012-03-16
• [Presentation] Target-cell dependent synaptic modulation of inhibitory synapses by nitric oxide in rat insular cortex (2012)
  • Author(s): Yamamoto K, Koshikawa N, Kobayashi M
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都国際会議場,京都
  • Year and Date: 2012-03-15
• [Presentation] Spatiotemporal profiles of long-term potentiation in rat insular cortex : an optical imaging study (2011)
  • Author(s): Mizoguchi N, Fujita S, Koshikawa N, Kobayashi M
  • Organizer: 41st Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC, U. S. A
  • Year and Date: 20111112-16
• [Presentation] Postsynaptic cell type-dependent modulation of inhibitory synaptic transmission by nitric oxide in rat insular cortex (2011)
  • Author(s): Yamamoto K, Koshikawa N, Kobayashi M
  • Organizer: 41st Annual Meeting of Society for Neuroscience
  • Place of Presentation: Washington DC, U. S. A
  • Year and Date: 20111112-16
• [Presentation] Physiological and morphological features of layer II/III pyramidal cells in rat insular cortex (2011)
  • Author(s): Adachi K, Koshikawa N, Kobayashi M
  • Organizer: 8th IBRO World Congress of Neuroscience
  • Place of Presentation: Florence, Italy
  • Year and Date: 20110714-18
• [Presentation] Reciprocal actions of leptin on excitatory and inhibitory synaptic transmission between pyramidal and fast spiking cells in rat cerebral cortex (2011)
  • Author(s): Takei, H, Shirakawa T, Koshikawa N, Kobayashi M
  • Organizer: 8th IBRO World Congress of Neuroscience
  • Place of Presentation: Florence, Italy
  • Year and Date: 20110714-18
• [Presentation] Insulin increases spike firing frequency via PI3-K but not MAPK cascade in rat cortical pyramidal cells (2011)
  • Author(s): Takei H, Koshikawa N, Kobayashi M
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜,神奈川
  • Year and Date: 2011-03-23
• [Presentation] Pilocarpine-induced status epilepticus causes hyper-excitatory propagation and interneuron loss in rat agranular insular cortex (2010)
  • Author(s): Fujita S, Chen S, Mizoguchi N, Koshikawa K, Kobayashi M
  • Organizer: 40th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, U. S. A
  • Year and Date: 20101113-17
• [Presentation] β-Adrenoceptors differentially regulate inhibitory synaptic transmission depending on presynaptic interneuron subtype in rat cerebral cortex (2010)
  • Author(s): Koyanagi Y, Oi Y, Koshikawa K, Kobayashi M
  • Organizer: 40th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, U. S. A
  • Year and Date: 20101113-17
• [Presentation] Postsynaptic cell type-dependent cholinergic regulation of GABAergic synaptic transmission in rat insular cortex (2010)
  • Author(s): Yamamoto K, Koshikawa K, Kobayashi M
  • Organizer: 40th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, U. S. A
  • Year and Date: 20101113-17
• [Presentation] Inter-and intracolumnar desynchronization by presynaptic GABA_B inhibition in the rat barrel cortex (2010)
  • Author(s): Saito M, Sato H, Toyoda H, Kobayashi M, Althof D, Kulik A, Shigemoto R, Kang Y
  • Organizer: 40th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego, U. S. A
  • Year and Date: 20101113-17
• [Presentation] Regulation of excitatory propagation by GABA(A) and GABA(B) receptors in the insular cortex (2010)
  • Author(s): Fujita S, Mizoguchi N, Koshikawa N, Kobayashi M
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場,大阪
  • Year and Date: 20100316-18
• [Presentation] Activation of dopamine D2 receptors suppresses lateral inhibition between medium spiny neurons in the nucleus accumbens (2010)
  • Author(s): Kohnomi S, Koshikawa N, Kobayashi M
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場,大阪
  • Year and Date: 20100316-18
• [Presentation] β-Adrenoceptors differentially modulate inhibitory synaptic transmission depending on presynaptic interneuron subtype (2010)
  • Author(s): Kobayashi M, Koyanagi Y, Yamamoto K, Koshikawa N
  • Organizer: Neuro2010
  • Place of Presentation: 神戸国際会議場,兵庫
  • Year and Date: 2010-09-03
• [Presentation] Postsynaptic cell type-dependent cholinergic regulation of GABAergic synaptic transmission in rat insular cortex (2010)
  • Author(s): Yamamoto K, Kobayashi M, Koshikawa N
  • Organizer: Neuro2010
  • Place of Presentation: 神戸国際会議場,兵庫
  • Year and Date: 2010-09-02
• [Presentation] Functional connectivity of rat insular cortex revealed by optical imaging technique (2009)
  • Author(s): Fujita S, Oi Y, Koshikawa K, Kobayashi M
  • Organizer: 39th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Chicago, U. S. A
  • Year and Date: 20091017-21
• [Presentation] Functional mapping of gustatory neurons in the insular cortex revealed by pERK-immunohistochemistry and in vivo optical imaging (2009)
  • Author(s): Kobayashi M, Fujita S, Koshikawa K
  • Organizer: 39th Annual Meeting of Society for Neuroscience
  • Place of Presentation: Chicago, U. S. A
  • Year and Date: 20091017-21
• [Presentation] Physiological features of pyramidal cells in rat insular cortex revealed by in vivo whole-cell patch clamp recording (2009)
  • Author(s): Adachi K, Fujita S, Sakagami H, Koshikawa N, Kobayashi M
  • Organizer: IUPS 2009
  • Place of Presentation: Kyoto
  • Year and Date: 20090727-0801
• [Presentation] Functional connectivity in rat insular cortex revealed by in vivo optical imaging (2009)
  • Author(s): Fujita S, Adachi K, Koshikawa N, Kobayashi M
  • Organizer: IUPS 2009
  • Place of Presentation: Kyoto
  • Year and Date: 20090727-0801
• [Presentation] Differential modulation of glutamatergic and GABAergic synaptic transmission by activating alpha1-and beta-adrenoceptors in rat cerebral cortex (2008)
  • Author(s): Koyanagi Y, Kobayashi M, Koshikawa N
  • Organizer: 6th Forum of European Neuroscience
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 20080712-16
• [Book] Macroscopic connection of rat insular cortex : anatomical bases underlying its physiological functions. In : Translating Mechanisms of Orofacial Neurological Disorder. (2011)
  • Author(s): Kobayashi M
  • Total Pages: 285-303
  • Publisher: London, Academic Press
• [Remarks]
  • URL: http://www.dent.nihon-u.ac.jp/pharm/index.htm