2010 Fiscal Year Final Research Report
The function of microRNA during the development of tongue and masseter muscles
| Project/Area Number |
20592190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
YAMANE AKIRA Tsurumi University, 歯学部, 教授 (20166763)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUI Tadayoshi 鶴見大学, 歯学部, 助教 (10267544)
SUGA Takeo 鶴見大学, 歯学部, 講師 (40247333)
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| Project Period (FY) |
2008 – 2010
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| Keywords | miRNA / 舌筋 / 咀嚼筋 / マイクロアレイ / Real-time PCR / in situ hybridization |
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| Research Abstract |
In the present study, the expressions of microRNA (miRNA) was analyzed during the embryonic development of mouse tongue muscle. The expression levels of miR-1 and 24 increased with the embryonic development and peaked between embryonic day (E) 13 and 15 during which tongue muscle cells are actively differentiating. On the contrary, those of miR-199a and 199b peaked at the beginning of the tongue muscle development (E11) and decreased thereafter. These results suggest that miR-1 and 24 are involved in the differentiation of tongue muscle cells.
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