2010 Fiscal Year Final Research Report
Analysis of the elevated expression of cartducin gene in osteosarcoma and the mechanisms of tumor development
| Project/Area Number |
20592197
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka University |
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Principal Investigator |
MAEDA Takashi Osaka University, 大学院・歯学研究科, 講師 (80324789)
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| Co-Investigator(Kenkyū-buntansha) |
FURUKAWA SOUHEI 大阪大学, 大学院・歯学研究科, 教授 (80173524)
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| Project Period (FY) |
2008 – 2010
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| Keywords | カートデューシン / 骨肉腫細胞 / 増殖 / 遊走 / 浸潤 / ERK1 / 2 |
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| Research Abstract |
Cartducin is expressed in human osteosarcomas. The mRNA level of Cartducin was increased in murine osteosarcoma cell lines compared with its level in normal murine osteoblastic cells. The protein level of Cartducin was also increased in these osteosarcoma cell lines. Stimulation of these osteosarcoma cells by Cartducin promoted tumor cell growth but not migration in vitro. Further, Cartducin stimulation led to the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in these osteosarcoma cell lines. Our results suggest that Cartducin expression may play a role in osteosarcoma tumor growth associated with activation of the ERK1/2 signaling pathway.
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Research Products
(12 results)
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[Journal Article] Assessment of influence of smoking, drinking, leukoplakia and dental irritation on local control of early oral tongue carcinoma treated with brachytherapy : age and dental factors are potential prognostic factors.2009
Author(s)
Yamazaki H, Inoue T, Yoshida K, Kotsuma T, Yoshioka Y, koizumi M, Furukawa S, Kakimoto N, Shimizutani K, Nishimura T.
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Journal Title
Peer Reviewed
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