2010 Fiscal Year Final Research Report
Identification of functional fimbria domain of periodontopathogen for the clinical application
| Project/Area Number |
20592198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka University |
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Principal Investigator |
MORISAKI Ichijiro Osaka University, 歯学部附属病院, 教授 (30116115)
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| Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Shigehisa 大阪大学, 歯学部附属病院, 准教授 (00283797)
MURAKAMI Jumpei 大阪大学, 歯学部附属病院, 助教 (70362689)
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| Co-Investigator(Renkei-kenkyūsha) |
AMANO Atsuo 大阪大学, 大学院・歯学研究科, 教授 (50193024)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 免疫 / 感染 / 炎症 / 歯学 / 歯周病 / オートファジー |
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| Research Abstract |
Porpnyromonas gingivalis, a periodontal pathogen, can enter host periodontal cells via endocytic pathway, which is involved in the disease progression. The present study was performed to elucidate the mechanism of the chronic situation of periodontal diseases in terms of the virulence of fimbrillin and of the bacterial intracellular localization. P.gingivalis was invaded by gingival epithelial cells and exited to extracelluolar milieu. This study suggests that the exit of P.gingivalis from gingival epithelial cells is mediated by Rabll, RalA, and exocyst complex. It also suggests that P.gingivalis can avoide the innate immune response, which can lead to the chronic situation of periodontal diseases.
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