2010 Fiscal Year Final Research Report
Autoimmune Disease of FEN1 Transgenic Mouse
| Project/Area Number |
20592204
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
KIMURA Yasuo Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (30253686)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30172406)
HOTOKEZAKA Yuka 長崎大学, 大学病院, 講師 (10244089)
TASHIRO Shigeki 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20300882)
TAKAGI Yukinori 長崎大学, 大学院・医歯薬学総合研究科, 助教 (30295084)
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| Project Period (FY) |
2008 – 2010
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| Keywords | FEN1 / 自己免疫疾患 / MRI / 拡散強調撮像 |
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| Research Abstract |
I performed various examination in FEN1 transgenic mouse, but was not able to confirm it whether autoimmune disease developed. I confirmed the lymphocyte permeation of the salivary gland (submandibular gland, sublingual gland) in the IQI mouse which was a mouse of the autoimmune disease instead. However, it was difficult to confirm a meaningful difference between a normal mouse by MR imaging (diffusion emphasis imaging) about the minute change of these salivary glands.
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