2010 Fiscal Year Final Research Report
Involvement of obesity in oral carcinogenesis using animal models
| Project/Area Number |
20592209
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
TANAKA Takuji Kanazawa Medical University, 医学部, 客員教授 (40126743)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIE Shigeyuki 金沢医科大学, 医学部, 教授 (60187648)
YASUI Yumiko 金沢医科大学, 医学部, 助教 (90434472)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 実験腫瘍学 |
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| Research Abstract |
We investigated whether obesity influences oral (tongue) carcinogenesis using obese model animals, such as db/db and ob/ob mice. The results indicated that the obese mice were highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis when compared to their wild types (WT) of mice. In addition, the susceptibility was high in db/db mice in comparison with ob/ob mice. The immunohistochemical expression of pro-inflammatory cytokines (IL-1α, IL-1β, interleukin-4, interleukin-6, interleukin-8, and TNF-α) in the tongue squamous cell carcinomas which developed in the db/db mice were significantly greater than that developed in the WT mice (p<0.05-p<0.01). However, there were no significant differences in the expressions of NF-κB, Stat3, and Nrf2 between the obese and WT mice. Our results may suggest that overexpression of these pro-inflammatory cytokines plays an important role in highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis in obese mice.
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