The role of T cells migration in periodontitis

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592213
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Osaka Dental University
• Principal Investigator: GODA Seiji Osaka Dental University, 歯学部, 講師 (70351476)
• Co-Investigator(Kenkyū-buntansha): DOMAE Eisuke 大阪歯科大学, 歯学部, 助教 (50454559) ; IKEO Takashi 大阪歯科大学, 歯学部, 教授 (40159603) ; DOMAE Naochika 大阪歯科大学, 歯学部, 名誉教授 (60115889)
• Project Period (FY): 2008 – 2010
• Keywords: 歯学 / 細胞・組織 / シグナル伝達 / 蛋白質

Research Abstract

T cells play a key role in periodontitis through their ability to migrate into tissues. CXCL12 is one of the chemokines that promote leukocytes invasion and migration into tissues, while the exact molecular mechanisms are not clear at present. In this study, we showed that CXCL12 significantly enhances T cells invasion into type I collagen by the catalytic activity of MMP-1. The production of pro-MMP-1 with CXCL12 required activation of JAK. Confocal immunofluorescence study suggests that MMP-1 is not localized on CXCL-12-stimulated JAK knock down T cell surface.

Research Products

• [Journal Article] β1-integrindependent macrophage migration is regulated by MAP kinase. (2011)
  • Author(s): SAKATA T, GODA S, OGAWA Y, IKEO T, MORITA S
  • Journal Title: J Oral Tissue Engin 8 Pages: 124-132
  • Peer Reviewed
• [Journal Article] Kinetics of p120-catenin in a human gingival cancer cell line treated with ZD1839. (2010)
  • Author(s): TAMURA I, WATO M, KAMADA A, GODA S, YOSHIKAWA Y, DOMAE E, TANAKA A, IKEO T
  • Journal Title: J Osaka Dent Univ 44 Pages: 169-175
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase 1 produced by CXCL12 stimulation on NK92 cells. (2009)
  • Author(s): INOUE H, GODA S, DOMAE N, NOSAKA K, NAKAI M, UCHIHASHI K, NISHIKAWA Y
  • Journal Title: J Osaka Dent Univ 43 Pages: 163-167
  • Peer Reviewed
• [Journal Article] Effect of adiponectin on gene expression profiles in osteoblasts. (2009)
  • Author(s): TANABE K, KAMADA A, GODA S, IKEO T
  • Journal Title: J Oral Tissue Engin 7 Pages: 99-106
  • Peer Reviewed
• [Journal Article] Effect of tyrosine kinase on TCR-mediated activation of integrin. (2009)
  • Author(s): ITSUSAKI H, GODA S, KAMADA A, IKEO T
  • Journal Title: J Oral Tissue Engin 7 Pages: 81-88
  • Peer Reviewed
• [Journal Article] Gene expression of adipo- cytokine receptors during osteoblastic defferentiation. (2009)
  • Author(s): KAMADA A, IKEO T, YOSHIKAWA Y, DOMAE E, GODA S, TAMURA I, TANABE K, TANABE J, ITSUSAKI H, KINOSHITA G, KITANO T, KIKUCHI Y, OKAZAKI J
  • Journal Title: J Oral Tissue Engin 7 Pages: 53-60
  • Peer Reviewed
• [Journal Article] CD54 contributes for NK cells cytotoxicity. (2009)
  • Author(s): YOSHIKADO R, GODA S, MORITA S
  • Journal Title: J Oral Tissue Engin 6 Pages: 194-200
  • Peer Reviewed
• [Journal Article] Enamel matrix derivative protein stimulated wound healing via phosphoinositide 3-Kinase. (2009)
  • Author(s): GODA S, KANESHITA Y, INOUE H, DOMAE E, IKEO T, IIDA J, DOMAE N
  • Journal Title: J Periodontol 80 Pages: 1631-1637
  • Peer Reviewed
• [Journal Article] エムドゲインが骨芽細胞に及ぼす影響 (2009)
  • Author(s): 合田征司,池尾隆
  • Journal Title: 日本臨床歯周病学会会誌 27 Pages: 49-51
• [Journal Article] Influence of adipocytokines on differenttiation of pro-osteoblastic cells. (2008)
  • Author(s): KAMADA A, IKEO T,, YOSHIKAWA Y, DOMAE E, GODA S, TAMURA I, KON-I H, OKAZAKI J, KAWAMOTO A, KOMASA Y, TODA I, SUWA F
  • Journal Title: J Oral Tissue Engin 6 Pages: 17-23
  • Peer Reviewed
• [Journal Article] Effects of PI-3 in integrin activation stimulated by CXCL12. (2008)
  • Author(s): MAEDA J, GODA S, IKEO T
  • Journal Title: J Oral Tissue Engin 6 Pages: 9-16
  • Peer Reviewed
• [Journal Article] Impaired TCR signaling through dys-function of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells. (2008)
  • Author(s): JIN ZX, HUANG CR, DONG L, GODA S, KAWANAMI T, SAWAKI T, SAKAI T, TONG XP, MASAKI Y, FUKUSHIMA T, TANAKA M, MIMORI T, TOJO H, BLOOM ET, OKAZAKI T, UMEHARA H
  • Journal Title: Int Immunol 20 Pages: 1427-1437
  • Peer Reviewed
• [Journal Article] Emdogain stimulates matrix degradation by osteoblasts. (2008)
  • Author(s): GODA S, INOUE H, KANESHITA Y, NAGANO Y, IKEO T, IIDA J, DOMAE N
  • Journal Title: J Dent Res 87 Pages: 782-787
  • Peer Reviewed
• [Journal Article] The effect of Methyl-β-cyclodextrin on the differentiation of RAW264 cells into osteoclasts. (2008)
  • Author(s): OGAWA Y, GODA S, MORITA S
  • Journal Title: Oral Sci International 5 Pages: 15-23
  • Peer Reviewed
• [Presentation] Epidermal growth factor receptor inhibitor Ag1439 reduces phosphor-rylation of P120-catenin in human oral cancer. (2010)
  • Author(s): TAMURA I, KAMADA A, GODA S, YOSHIKAWA Y, DOMAE E, IKEO T
  • Organizer: ASCB 50^<th> Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2010-12-13
• [Presentation] Adiponectin機能ドメインの骨芽細胞分化に及ぼす影響 (2010)
  • Author(s): 鎌田愛子,田村功,合田征司,吉川美弘,堂前英資,池尾隆
  • Organizer: 第8回日本再生歯科医学会学術大会・総会
  • Place of Presentation: 愛知学院大学歯学部(愛知県)
  • Year and Date: 2010-10-30
• [Presentation] ライセニンが破骨細胞分化に及ぼす影響 (2010)
  • Author(s): 堂前英資,合田征司,小川裕美子,竹内摂,吉川美弘,田村功,鎌田愛子,森田章介,山本一世,池尾隆
  • Organizer: 第8回日本再生歯科医学会学術大会・総会
  • Place of Presentation: 愛知学院大学歯学部(愛知県)
  • Year and Date: 2010-10-30
• [Presentation] MAP kinaseはβ1-インテグリンを介したマクロファージの遊走を調整する (2010)
  • Author(s): 坂田岳一,合田征司,小川裕美子,池尾隆,森田章介
  • Organizer: 第8回日本再生歯科医学会学術大会・総会
  • Place of Presentation: 愛知学院大学歯学部(愛知県)
  • Year and Date: 2010-10-30
• [Presentation] RAW264細胞におけるCXCL12刺激による細胞遊走のERK1/2MAPKの影響 (2010)
  • Author(s): 坂田岳一,合田征司,小川裕美子,吉門良祐,吉田博昭,森田章介
  • Organizer: 第55回日本口腔外科学会総会・学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2010-10-18
• [Presentation] Probable roles of adiponectin functional domains in osteoblastic differentiation. (2010)
  • Author(s): KAMADA A, IKEO T, YOSHIKAWA Y, DOMAE E, GODA S, TAMURA I
  • Organizer: ASBMR 2010 Annual Meeting
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2010-10-16
• [Presentation] Expression of adiponectin receptors in osteo-blastic cells. (2010)
  • Author(s): IKEO T, KAMADA A, YOSHIKAWA Y, DOMAE E, GODA S, TAMURA I
  • Organizer: ASBMR 2010 Annual Meeting
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2010-10-16
• [Presentation] 骨芽細胞遊走に及ぼすエムドゲインの影響 (2010)
  • Author(s): 川崎俊也,合田征司,氏井庸介,池尾隆,松本尚之
  • Organizer: 第69回日本矯正歯科学会大会第3回日韓ジョイントミーティング
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-09-29
• [Presentation] エムドゲインがMMPs産生に及ぼす影響 (2010)
  • Author(s): 氏井庸介,川崎俊也,合田征司,池尾隆,松本尚之
  • Organizer: 第69回日本矯正歯科学会大会第3回日韓ジョイントミーティング
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-09-29
• [Presentation] β1-インテグリン依存性マクロファージ移動はMAPキナーゼとPI3-キナーゼにより制御される (2010)
  • Author(s): 坂田岳一,合田征司,小川裕美子,池尾隆
  • Organizer: 第52回歯科基礎医学会学術大会・総会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-09-22
• [Presentation] 半導体レーザーの象牙質透過性と歯髄細胞におよぼす影響について (2010)
  • Author(s): 田中芳人,竹内摂,合田征司,吉川一志,山本一世
  • Organizer: 第10回日本歯科用レーザー学会
  • Place of Presentation: 日本歯科大学(東京都)
  • Year and Date: 2010-09-05
• [Presentation] Lyseninが破骨細胞分化に及ぼす影響 (2010)
  • Author(s): 坂田岳一,合田征司,小川裕美子,池尾隆,森田章介
  • Organizer: 第41回日本口腔外科学会近畿地方会
  • Place of Presentation: 和歌山県立医科大学(和歌山県)
  • Year and Date: 2010-06-19
• [Presentation] 細胞遊走に及ぼすエムドゲインの影響 (2010)
  • Author(s): 合田征司,池野真紀,堂前尚親,池尾隆
  • Organizer: 第10回日本抗加齢医学会総会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-06-12
• [Presentation] 細胞遊走に及ぼすエムドゲインの影響 (2010)
  • Author(s): 合田征司,竹内摂,保尾謙三,吉川一志,加藤侑,林宏行,山本一世,池尾隆
  • Organizer: 日本歯科保存学会2010年度春季学術大会(132回)
  • Place of Presentation: 崇城大学市民ホール(熊本県)
  • Year and Date: 2010-06-05
• [Presentation] Effect of adiponectin functional domains on gene expression in MC3T3-E1 cells. (2010)
  • Author(s): KAMADA A, TAMURA I, GODA S, YOSHIKAWA Y, DOMAE E, OKAZAKI J, KAWAMOTO A, KOMASA Y, TODA I, SUWA F, IKEO T
  • Organizer: 第8回日本歯科骨粗鬆症研究会-歯科再生医療と骨粗鬆症-
  • Place of Presentation: 東京医科歯科大学歯学部(東京都)
  • Year and Date: 2010-04-04
• [Presentation] Lipid rafts regulate RANKL signaling pathways in RAW264 cells. (2010)
  • Author(s): UJII Y, GODA S, DOMAE E, SAKATA T, MORITA S, MATSUMOTO N, KAWASAKI T, HAYASHI H, KATO Y, YAMAMOTO K, TAKEUCHI O, YASUO K, YOSHIKAWA Y, TAMURA I, KAMADA A, 池尾隆
  • Organizer: 第8回日本歯科骨粗鬆症研究会-歯科再生医療と骨粗鬆症-
  • Place of Presentation: 東京医科歯科大学歯学部(東京都)
  • Year and Date: 2010-04-04
• [Presentation] Kinetics of plazo catenin in human gingival cancer cell line treated with ZD1893. (2009)
  • Author(s): TAMURA I, KAMADA A, GODA S, YOSHIKAWA Y, DOMAE E, IKEO T
  • Organizer: ASCB 49^<th> Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2009-12-06
• [Presentation] 破骨細胞分化におよぼすLipid raftsの影響 (2009)
  • Author(s): 氏井庸介,金下裕己,中島紗恵子,合田征司,池尾隆,松本尚之
  • Organizer: 第68回日本矯正歯科学会大会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2009-11-18
• [Presentation] 破骨細胞分化におけるLipid raftの役割 (2009)
  • Author(s): 竹内摂,合田征司,保尾謙三,吉川一志,畑下芳史,池尾隆,山本一世
  • Organizer: 日本歯科保存学会2009年度秋季学術大会(第131回)
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2009-10-30
• [Presentation] 破骨細胞分化の解明における新型倒立型共焦点レーザー顕微鏡導入の必要性その1 (2009)
  • Author(s): 堂前英資,合田征司,井上博,竹内摂,山本一世,池尾隆
  • Organizer: 大阪歯科大学中央歯学研究所設備備品購入のための研究発表会
  • Place of Presentation: 大阪歯科大学(大阪府)
  • Year and Date: 2009-09-16
• [Presentation] 破骨細胞分化の解明における新型倒立型共焦点レーザー顕微鏡導入の必要性 その2 (2009)
  • Author(s): 竹内摂,合田征司,井上博,堂前英資,山本一世,池尾隆
  • Organizer: 大阪歯科大学中央歯学研究所設備備品購入のための研究発表会
  • Place of Presentation: 大阪歯科大学(大阪府)
  • Year and Date: 2009-09-16
• [Presentation] 骨芽細胞におけるadipocytokine受容体の発現 (2009)
  • Author(s): 鎌田愛子,田村功,合田征司,吉川美弘,堂前英資,池尾隆
  • Organizer: 第7回日本再生歯科医学会総会学術大会
  • Place of Presentation: 九州歯科大学講堂(福岡県)
  • Year and Date: 2009-09-12
• [Presentation] エムドゲイン刺激が骨芽細胞のMMP-1産生に及ぼす影響 (2009)
  • Author(s): 堂前英資,合田征司,金下祐己,竹内摂,坂田岳一,氏井庸介,保尾謙三,鎌田愛子,田村功,吉川美弘,森田章介,山本一世,松本尚之,池尾隆
  • Organizer: 第7回日本再生歯科医学会総会学術大会
  • Place of Presentation: 九州歯科大学講堂(福岡県)
  • Year and Date: 2009-09-12
• [Presentation] Relationship of gene expression between adiponectin receptors and osteoblastic differentiation markers. (2009)
  • Author(s): IKEO T, KAMADA A, YOSHIKAWA Y, DOMAE E, GODA S, TAMURA I, KAWAMOTO A, OKAZAKI J, KOMASA Y, TAKAISHI Y, MIKI T, FUJITA T
  • Organizer: ASBMR 31^<st> Annual Meeting
  • Place of Presentation: Denver, USA
  • Year and Date: 2009-09-11
• [Presentation] Effect of different form of adiponectin on gene expression profiles in osteoblasts. (2009)
  • Author(s): KAMADA A, IKEO T, YOSHIKAWA Y, DOMAE E, GODA S, TAMURA I, KAWAMOTO A, OKAZAKI J, KOMASA Y, TAKAISHI Y, MIKI T, FUJITA T
  • Organizer: ASBMR 31^<st> Annual Meeting
  • Place of Presentation: Denver, USA
  • Year and Date: 2009-09-11
• [Presentation] Effect of adiponectin on gene expression profiles in osteoblasts. (2009)
  • Author(s): 田辺薫,鎌田愛子,合田征司,池尾隆
  • Organizer: 第51回歯科基礎医学会学術大会・総会
  • Place of Presentation: 朱鷺メッセ 新潟コンベンションセンター(福岡県)
  • Year and Date: 2009-09-10
• [Presentation] CXCL8刺激NK細胞におけるI型コラーゲンに対する浸潤と遊走について (2009)
  • Author(s): 井上博,合田征司,池尾隆,堂前尚親,西川泰央
  • Organizer: 第51回歯科基礎医学会学術大会・総会
  • Place of Presentation: 朱鷺メッセ 新潟コンベンションセンター(福岡県)
  • Year and Date: 2009-09-10
• [Presentation] Effect of Tyrosine kinase on TCR-mediated activation of integrin. (2009)
  • Author(s): ITSUSAKI H, GODSA S, KAMADA A, IKEO T
  • Organizer: 第51回歯科基礎医学会学術大会・総会
  • Place of Presentation: 朱鷺メッセ新潟コンベンションセンター(福岡県)
  • Year and Date: 2009-09-10
• [Presentation] 骨芽細胞におけるエムドゲインがMMPs産生に及ぼす影響 (2009)
  • Author(s): 合田征司,竹内修,吉川一志,保尾謙三,山本一世,池尾隆
  • Organizer: 日本歯科保存学会2009年度春季学術大会(第130回)
  • Place of Presentation: 札幌コンベンションセンターSORA(北海道)
  • Year and Date: 2009-06-11
• [Presentation] エムドゲインが骨芽細胞に及ぼす影響 (2009)
  • Author(s): 合田征司,池野真紀,堂前尚親,池尾隆
  • Organizer: 第9回日本抗加齢医学会総会
  • Place of Presentation: ホテル日航東京(東京都)
  • Year and Date: 2009-05-28
• [Presentation] Selective removal of caries using laser absorption of 805-nm Diode, Er YAG, and Co2 lasers with experimental caries-detection dye solutions. (2009)
  • Author(s): YOSHIKAWA K, GODA S, YAMAMOTO K, AWAZU K
  • Organizer: Academy of Laser Dentistry 16^<th> Annual Conference
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2009-04-25
• [Presentation] 歯随細胞における炎症性サイトカインの影響 (2009)
  • Author(s): 竹内摂,吉川一志,合田征司,堂前英資,池尾隆,山本一世
  • Organizer: 518回大阪歯科学会例会
  • Place of Presentation: 大阪歯科大学(大阪府)
  • Year and Date: 2009-04-11
• [Presentation] Lysenin suppresses osteoclast differentiation by modulating RANK signaling pathways. (2009)
  • Author(s): GODA S, OGAWA Y, UJII Y, DOMAE E, YOSHIKAWA Y, TAMURA I, KAMADA A, MATSUMOTO N, MORITA S, IKEO T
  • Organizer: 日本歯科骨粗鬆症研究会第7回学術大会・総会
  • Place of Presentation: 大阪歯科大学(大阪府)
  • Year and Date: 2009-02-22
• [Presentation] Adipocytokine mediate growth and differentiation of human polpal cells. (2008)
  • Author(s): TAMURA I, KAMADA A, GODA S, YOSHIKAWA Y, DOMAE E, IKEO T
  • Organizer: ASCB 48^<th> Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2008-12-14
• [Presentation] NK細胞殺傷へのCD54の関与 (2008)
  • Author(s): 吉門良祐,合田征司,森田章介
  • Organizer: 第516回大阪歯科学会例会
  • Place of Presentation: 大阪歯科大学(大阪府)
  • Year and Date: 2008-12-13
• [Presentation] T細胞T細胞活性化と免疫応答(細胞レベルでの解析を中心に)細胞膜スフィンゴミエリンとT細胞機能との関連解析 (2008)
  • Author(s): XIONG JZ, PENG TX, RI H,澤木俊興,坂井知之,河南崇興,田中真生,正木康史,福島俊洋,合田征司,岡崎俊朗,梅原久範
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2008-12-02
• [Presentation] TNF-α刺激によるヒト歯髄由来線維芽細胞のMMPs産生について (2008)
  • Author(s): 竹内摂,吉川一志,合田征司,河村昌哲,三木秀治,池尾隆,山本一世
  • Organizer: 日本歯科保存学会2008年度秋季学術大会(第129回)
  • Place of Presentation: 富山国際会議場(富山県)
  • Year and Date: 2008-11-07
• [Presentation] Methyl-β-cyclodextrin suppresses osteoclastogenesis by modulating the MAPKs signaling pathways. (2008)
  • Author(s): DOMAE E, GODA S, OGAWA Y, TAKEUCHI O, YOSHIKADO R, SAKATA T, YOSHIKAWA Y, TAMURA I, KAMADA A, YAMAMOTO K, MORITA S, IKEO T
  • Organizer: The 4^<th> Sino-Japanese Conference on Stomatology
  • Place of Presentation: Sian China
  • Year and Date: 2008-09-28
• [Presentation] Suppression of osteoclastogenesis by Lysenin a sphingomyelin specific toxin by modulationg RANL signal pathways. (2008)
  • Author(s): GODA S, DOMAE E, OGAWA Y, TAKEUCHI O, YOSHIKADO R, SAKATA T, YOSHIKAWA Y, TAMURA I, KAMADA A, YAMAMOTO K, MORITA S, IKEO T
  • Organizer: The 4^<th> Sino-Japanese Conference on Stomatology
  • Place of Presentation: Sian, China
  • Year and Date: 2008-09-28
• [Presentation] Adipocytokine influences differentiation of osteoblasts. (2008)
  • Author(s): KAMADA A, IKEO T, YOSHIKAWA Y, DOMAE E, GODA S, TAMURA I, KAWAMOTO A, OKAZAKI J, KOMASA Y, TODA I, SUWA F
  • Organizer: The 4^<th> Sino-Japanese Conference on Stomatology
  • Place of Presentation: Sian, China
  • Year and Date: 2008-09-28
• [Presentation] The traditional Chinese medicine improbes the expression of adipocytokine mRNA in simple obesity mouse. (2008)
  • Author(s): IKEO T, KAMADA A, YOSHIKAWA Y, DOMAE E, GODA S, TAMURA I, TAKAISHI Y
  • Organizer: The 4^<th> Sino-Japanese Conference on Stomatology
  • Place of Presentation: Sian, China
  • Year and Date: 2008-09-28
• [Presentation] Effects of methyl-β-cyclodextrin on osteoclastogenesis in RAW 264 cell. (2008)
  • Author(s): DOMAE E, GODA S, OGAWA Y, TAKEUCHI O, YOSHIKADO R, SAKATA T, YOSHIKAWA Y, TAMURA I, KAMADA A, YAMAMOTO K, MORITA S, IKEO T
  • Organizer: DI Annual World Dental Congress
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2008-09-26
• [Presentation] ケモカイン刺激NK細胞におけるMatrix metallopro-teinase-1の発現について (2008)
  • Author(s): 井上博,合田征司,池尾隆,堂前尚親,西川泰央
  • Organizer: 第50回日本歯科基礎医学会
  • Place of Presentation: TOC有明コンベンションホール(東京都)
  • Year and Date: 2008-09-25
• [Presentation] Effects of PI-3 K in integrin activations stimulated by CXCL12. (2008)
  • Author(s): 前田潤一郎,合田征司,池尾隆
  • Organizer: 第50回日本歯科基礎医学会
  • Place of Presentation: TOC有明コンベンションホール(東京都)
  • Year and Date: 2008-09-25
• [Presentation] EMD(エムドゲイン)が骨芽細胞様細胞に及ぼす影響 (2008)
  • Author(s): 合田征司,池尾隆
  • Organizer: 第50回日本歯科基礎医学会
  • Place of Presentation: TOC有明コンベンションホール(東京都)
  • Year and Date: 2008-09-23
• [Presentation] Heparan sulfate proteoglycans modulate osteogenic differentiation through heparin sulfate chains. (2008)
  • Author(s): KAMADA A, IKEO T, YOSHIKAWA Y, DOMAE E, GODA S, TAMURA I, KAWAMOTO A, OKAZAKI J, KOMASA Y, TAKAISHI Y, MIKI T, FUJITA T
  • Organizer: ASBMR 30^<th> Annual Meeting
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2008-09-12
• [Presentation] Various roles of syndecan family in osteoblastic cells. (2008)
  • Author(s): IKEO T, KAMADA A, YOSHIKAWA Y, DOMAE E, GODA S, TAMURA I, KAWAMOTO A, OKAZAKI J, KOMASA Y, TAKAISHI Y, MIKI T, FUJITA T
  • Organizer: ASBMR 30^<th> Annual Meeting
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2008-09-12
• [Presentation] Emdogain stimulates matrix degradation by osteoblasts. (2008)
  • Author(s): 合田征司, 池尾隆
  • Organizer: AAP 2008 Annual Meeting
  • Place of Presentation: Seattle, USA
  • Year and Date: 2008-09-08
• [Presentation] Lysenin inhibits RANKL induced osteoclast differentiation. (2008)
  • Author(s): TAKEUCHI O, GODA S, YOSHIKAWA K, OGAWA Y, IKEO T, YAMAMOTO K
  • Organizer: AAP 2008 Annual Meeting
  • Place of Presentation: Seattle, USA
  • Year and Date: 2008-09-08
• [Presentation] ヒト歯髄由来細胞の動態におけるアディポサイトカインの影響 (2008)
  • Author(s): 田村功,鎌田愛子,合田征司,吉川美弘,堂前英資,池尾隆
  • Organizer: 第3回日本再生歯科医学シンポジウム
  • Place of Presentation: 大阪大学(大阪府)
  • Year and Date: 2008-07-11
• [Presentation] エムドゲインが骨芽細胞に及ぼす影響 (2008)
  • Author(s): 合田征司,池尾隆
  • Organizer: 日本臨床歯周病学会第26回年次大会
  • Place of Presentation: 市川市文化会館(千葉県)
  • Year and Date: 2008-06-21
• [Presentation] Lipid raftsが破骨細胞分化に及ぼす影響 (2008)
  • Author(s): 合田征司,池野真紀,池尾隆,堂前尚親
  • Organizer: 第8回日本抗加齢医学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2008-06-06
• [Presentation] ゼラチナーゼが破骨細胞分化におよぼす影響 (2008)
  • Author(s): 池野真紀,合田征司,堂前尚親
  • Organizer: 第8回日本抗加齢医学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2008-06-06
• [Presentation] NK細胞のI型コラーゲンに対する浸潤と分解について (2008)
  • Author(s): 井上博,合田征司,金下祐己,松本尚之,池尾隆,堂前尚親
  • Organizer: 日本歯周病学会2008春季学術大会(第51回)
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2008-04-25
• [Book] メタボリックシンドロームと歯周疾患の発症.脂質代謝と骨代謝を踏まえた生化学からのアプローチ (2010)
  • Author(s): 池尾隆,鎌田愛子,合田征司
  • Total Pages: 387-397
  • Publisher: 日本歯科医師会雑誌日本歯科医師会