2010 Fiscal Year Final Research Report
The functional roles of IL-10 in periapical inflammation
| Project/Area Number |
20592222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUZUKI Noriyuki Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (20372451)
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| Research Collaborator |
STASHENKO Philip The Forsyth Institute
SASAKI Hajime The Forsyth Institute
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| Project Period (FY) |
2008 – 2010
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| Keywords | 根尖性歯周炎 / IL-10 / Th1サイトカイン |
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| Research Abstract |
The periapical lesion is a granuloma containing a mixed inflammatory infiltrate induced by local immune reaction, however, its pathogenesis and the mechanism of expansion are still unclear. In this study, we examined the roles of IL-10 and Th1 cytokines in periapical inflammation using knockout (KO) mice. We conclude that IL-12-dependent T cell-mediated responses seem to induce hyper periapical inflammation in IL-10 KO mice.
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Research Products
(6 results)
