2010 Fiscal Year Final Research Report

Development osseoinductive nano-textured implant and analysis of its gene network

Research Project

Project/Area Number	20592289
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Prosthetic dentistry
Research Institution	Nihon University
Principal Investigator	SATOH Yoshinori Nihon University, 歯学部, 教授 (70060051)
Co-Investigator(Kenkyū-buntansha)	INAGE Toshihiko 日本大学, 歯学部, 准教授 (90096769) KUWATA Fumiyuki 日本大学, 歯学部, 教授 (60120440)
Project Period (FY)	2008 – 2010
Keywords	歯学 / ナノ材料 / シグナル伝達 / 蛋白質 / 核酸
Research Abstract	A novel nano-surfaced titanium has been generated by irradiated with Femto-sec laser and demonstrate stimulation of proliferation and differentiation of rat bone stroma cells. Numbers of cultured cell were counted and expressions of collagen and osteocalcin were studied in vitro. The surface roughness was increased by laser irradiation. In the culture with nano-surfaced Ti, the numbers of cultured were increased than those of machined surface at 7 day and at 10 day after the culture. The number of osteocalcin-positive cell increased than that of collagen-positive cell by the immunohistochemistry at 10 day after the culture.

(3 results)