Influence of Restoring Occlusal Support with Removable Denture on secretory Immunoglobulin A and nerve growth factor in saliva

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592295
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Osaka Dental University
• Principal Investigator: MAEDA Teruta 大阪歯科大学, 歯学部・附属病院, 教授 (10103110)
• Project Period (FY): 2008 – 2010
• Keywords: 有床義歯補綴学 / ストレス / 咬合支持 / バイオマーカー

Research Abstract

Salivary stress biomarkers(cortisol, alpha-amylase, secretory immunoglobulin and nerve growth factor) were analyzed in patients without occlusal support in the molar regions. The relationship between before and after restoration by removable partial denture(s)(RPD) was studied. The concentrations of only cortisol and alpha-amylase immediately after treatment for the RPD were significantly higher than those 1 month after treatment. The present data suggest that wearing RPD became a source of stress. However, there were personal variations in concentration of biomarkers with and without RPD. When measuring stress reaction in patients, it is necessary to make various assessments.

Research Products

• [Journal Article] Influences of molar loss of rat on learning and memory (2009)
  • Author(s): Andoh T, Sakuma Y, Yamamoto S, Matsuno A, Maeda T, Kotani J
  • Journal Title: Journal of Prosthodontic Research Volume: 53 Pages: 155-160
  • Peer Reviewed
• [Journal Article] How changes in localized pressure under an experimental acrylic plate covering the palatal mucosa affect salivary cortisol concentration and α-amylase activity (2009)
  • Author(s): Ito H, Maeda T, Okazaki J
  • Journal Title: J Osaka Dent Univ Volume: 43 Pages: 71-81
  • Peer Reviewed
• [Journal Article] 実験的口蓋床による局部加圧が唾液中コルチゾール濃度およびα-アミラーゼ活性値に及ぼす影響 (2009)
  • Author(s): 伊藤秀高, 古川麻希子, 國場幸恒, 土居聖, 加藤尚, 松野彰仁, 奥田恵司, 田中康隆, 紺井拡隆, 前田照太, 岡崎定司
  • Journal Title: 歯科医学 Volume: 72 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Influence of uncomfortable removable partial dentures on stress hormone in saliva (2008)
  • Author(s): Kohno J, Maeda T, Inoue H
  • Journal Title: 日本顎頭蓋機能学会誌 Volume: 21 Pages: 1-6
  • Peer Reviewed
• [Presentation] Stress biomarkers in association with pain discomfort in maxillary palatal mucosa (2011)
  • Author(s): Maeda T, Furukawa M, Ito H
  • Organizer: The 14th Meeting of the International College of Prosthodontists
  • Place of Presentation: Hawaii
  • Year and Date: 2011-09-20
• [Presentation] Influence of forms and setting position of maxillary major connectors on salivary alpha-amylase activity and concentration of immunoglobulin (2011)
  • Author(s): Furukawa M, Maeda T, Kokuba Y, Matsuno A, Okazaki J
  • Organizer: The 14th Meeting of the International College of Prosthodontists
  • Place of Presentation: Hawaii
  • Year and Date: 2011-09-20
• [Presentation] Occlusal support loss affects bilateral intrastriatal dopamine feeding response in rats (2011)
  • Author(s): Kokuba Y, Okuda K, Kuremoto K, Maeda T, Okazaki J
  • Organizer: The 14th Meeting of the International College of Prosthodontists
  • Place of Presentation: Hawaii
  • Year and Date: 2011-09-20
• [Presentation] 上顎大連結子の形態と設定位置が唾液中アミラーゼに与える影響 (2011)
  • Author(s): 古川麻希子、前田照太、岡崎定司
  • Organizer: 日本補綴歯科学会
  • Place of Presentation: 広島市
  • Year and Date: 2011-05-21
• [Presentation] Influence of unpleasant and imperceptible spots under an experimental acrylic plate covering the palatal mucosa on salivary biochemical stress markers (2009)
  • Author(s): Maeda T, Furukawa M, Okazaki J
  • Organizer: 13th Meeting of the International College of Prosthodontists
  • Place of Presentation: Cape Town, South Africa
  • Year and Date: 2009-09-12