2010 Fiscal Year Final Research Report
Osteonecrosis of jaw bones induced by bisphosphonates : an approach to clarifying its underlying mechanism, prevention, and treatment
| Project/Area Number |
20592318
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
YAMAGUCHI Kouji Tohoku University, 大学院・歯学研究科, 大学院非常勤講師 (10372319)
|
|---|
| Research Collaborator |
ENDO Yasuo 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (50005039)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 口腔外科一般 / 顎骨壊死 |
|---|
| Research Abstract |
Osteonecrosis of the jawbone (ONJ) and its ensuing exposure induced by nitrogen-containing bisphosphonates (NBP) are taking much attention. Its underlying mechanism is not clear and there are no active methods for its prevention and treatment. Based on our findings in basic, animal experiments, we tried substitution of NBPs to etidronate (a non-NBP) for ONJ-patients with osteoporosis or tumor bone-metastasis, and observed a rapid removal of sequestra and a tendency of promoted curing. Etidronate, as a substitution drug for NBP, may be effective at treating or preventing NBP-induced ONJ or myelitis.
|
-
[Journal Article] Inhibition of necrotic actions of nitrogen-containing bisphosphonates (NBPs) and their elimination from bone by etidronate (a non-NBP) : a proposal for possible utilization of etidronate as a substitution drug for NBPs.2010
Author(s)
Oizumi T, Funayama H, Yamaguchi K, Yokoyama M, Takahashi H, Yamamoto M, Kuroishi T, Kumamoto H, Sasaki K, Kawamura H, Sugawara S, Endo Y
-
Journal Title
J Oral Maxillofac Surg. 68
Pages: 1043-1054
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Remarks] ホームページ等
