2010 Fiscal Year Final Research Report
An experimental study on histologic changes of osteogenesis and neurogenes is followed by osteoplasty of the mandible
| Project/Area Number |
20592323
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAKAGAWA Kiyomasa Kanazawa University, 医学系, 准教授 (30155676)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKATSUKA Shigeyuki 金沢大学, 附属病院, 講師 (00251926)
UEKI Kouichirou 金沢大学, 医学系, 助教 (40313663)
MARUKAWA Kouhei 金沢大学, 附属病院, 医員 (50444203)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 顎変形症 / 顎矯正手術 / 知覚神経麻痺 |
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| Research Abstract |
An experimental study of the postoperative changes on neurogenesis and neurogenic physiology has been carried out using rabbits. Purpose of the study was focused on microscopic changes in surgical sites of the saggital split osteotomy and distraction osteogenesis of the mandible. Experimental animals have divided into four groups. Osteogenesis and neurogenesis followed by surgical maneuver was evaluated histopathologically. Analyses have performed on distribution of osteogenic cells such as osteoblast and osteoclast, or bone morphogenetic protein (BMP) using histo-chemical methods. Results of the study have suggested that experimental groups showed consistent healing compared to sham control following both sagittal split osteotomy and distraction osteogenesis, irrespective of difference of the healing time.
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