2010 Fiscal Year Final Research Report
The research for gingival fibroblasts character and its effect on the wound healing
| Project/Area Number |
20592326
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
EBISAWA Katsumi Nagoya University, 医学部附属病院, 病院助教 (20397459)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NARITA Yuji 名古屋大学, 大学院・医学系研究科, 特任講師 (60378221)
KAGAMI Hideaki 東京大学, 医科学研究所, 客員准教授 (80242866)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 創傷治癒 / 口腔粘膜由来線維芽細胞 / 再生医療 |
|---|
| Research Abstract |
From comparison of expression profiles of genes in dermal and gingival fibroblasts, only 5% showed a significant difference in the levels of expression. Hierarchical clustering of total genes showed that the difference between gingival and dermal fibroblasts was larger than the difference between ages or gender of patients. Wound closure was significantly accelerated in the wells treated with conditioned medium from gingival fibroblasts than in wells treated with dermal fibroblast conditioned medium, suggesting the presence of functional factor(s) in the conditioned medium that accelerate cell motility/growth of keratinocytes. These results should provide the possibility of effective treatment, which could be genetically designed to provide a higher therapeutic effect by selecting the origin of fibroblasts since gingival and dermal fibroblasts show some unique characteristics in their gene expression profiles.
|
Research Products
(11 results)
