2010 Fiscal Year Final Research Report
Analysis of cleft palate pathogenesis caused by post-fusional rupture
| Project/Area Number |
20592332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
YAMADA Tomohiro Okayama University, 教育研究部・医療学系, 准教授 (60335619)
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| Co-Investigator(Kenkyū-buntansha) |
MISHIMA Katsuaki 山口大学, 大学院・医学系研究科, 准教授 (60304317)
HIRATA Azumi 大阪大学, 大学院・工学研究科, 特任研究員 (40263587)
MATSUMURA Tatsushi 岡山大学, 病院, 助教 (70432648)
MORITANI Norifumi 岡山大学, 病院, 助教 (60467751)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 口蓋裂 / マウス / ダイオキシン / 解離 / 接着因子 |
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| Research Abstract |
Mice treated with TCDD (2, 3, 7, 8-tetrachrolodibenzo dioxin) develop cleft palate following disruption, regardless the palate once fused. Factors related to the disruption of the palate, were considered for the lack of physical strength of the tissues. Therefore, intercellular adhesion molecule and basement membrane components were analyzed in this study. As a result, TCDD decreased expression of these molecules. Furthermore, morphologically bony hypoplasia was observed in the palatal bone of TCDD-treated group.
In conclusion, TCDD pathogenesis of cleft palate in mice was suggested to be caused by not only insufficient strength of palatal epithelium, but also hypoplasia of the muscles and bone.
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[Journal Article] Effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion.2010
Author(s)
Imura H, Yamada T, Mishima K, Fujiwara K, Kawaki H, Hirata A, Sogawa N, Ueno T, Sugahara T.
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Journal Title
Congenital Anomalies 50
Pages: 77-84
Peer Reviewed
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[Journal Article] Bone formation in a rat calvarial defect model after transplanting autogenous bone marrow with beta-tricalcium phosphate.2010
Author(s)
Shirasu N, Ueno T, Hirata A, Kagawa T, Kanou M, Sawaki M, Wakimoto M, Ota A, Moritani N, Imura H, Matsumura T, Yamada T., Yamachika E.
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Journal Title
Acta Histochemica 112
Pages: 270-277
Peer Reviewed
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[Presentation] 口唇口蓋裂に関する実験的研究-第124報-器官培養による口蓋突起癒合時の観察2010
Author(s)
井村英人, 平田あずみ, 山田朋弘, 南克浩, 新美照幸, 古川博雄, 三島克章, 藤原久美子, 鈴木聡, 菅原利夫, 前田初彦, 夏目長門
Organizer
第55回日本口腔外科学会総会
Place of Presentation
千葉
Year and Date
20101016-20101018
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[Presentation] Localization of heparanase during palatal bone formation in palatogenesis in mice.2009
Author(s)
Hirata A, Tsuji T, Ueno T, Yamada T, Imura H, Kagawa T, Matsumura T, Moritani N, Mishima K, Sugahara T, Nakamura N.
Organizer
36th European Symposium on Calcified Tissues
Place of Presentation
ウイーン
Year and Date
20090523-20090527
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