Trace element analysis of the tissue from the oral lichen planus patients by the PIXE method

2011 Fiscal Year Final Research Report

• Project/Area Number: 20592342
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Iwate Medical University
• Principal Investigator: SUGIYAMA Yoshiki 岩手医科大学, 歯学部, 教授 (00162909)
• Co-Investigator(Kenkyū-buntansha): SERA Kouichiro 岩手医科大学, 医学部, 教授 (00230855)
• Project Period (FY): 2008 – 2011
• Keywords: 歯学 / 臨床 / 分析化学 / 加速器 / 人間生活環境

Research Abstract

We made a comparative study of trace elements in the oral mucosa of 31 patients with oral lichen planus(OLP) and of 100 healthy persons by the Particle Induced X-ray Emission(PIXE) method in order to clarify the causes of OLP. The results were as follows : Seventeen trace elements and 11 contaminating elements were detected. As for the females over 30 years old, the OLP group showed significantly higher values of Si, Fe, Zn, Al and Sr than the control group. The mean values of the other essential and contaminating elements did not differ significantly between the groups, although there was a trend toward higher values in the OLP group. We found by the PIXE method that Zn, Fe and Pd, which are d-transitional elements, showed higher values in the oral mucosa of the OLP patients than in those of the healthy persons.

Research Products

• [Journal Article] Oral Lichenoid Drug Reaction with Autoantibodies in Peripheral Blood : Case Report (2011)
  • Author(s): Kumagai, A., Matsuo, M., Hoshi, H., Sato, H., Takeda, Y. and Sugiyama, Y.
  • Journal Title: Oral Sciense International Volume: 8 Pages: 29-33
  • Peer Reviewed
• [Journal Article] Studies on Changes of Elemental Concentration in a Human Body by Means of Analyses of Long Hairs on the Basis of the Standard-Free Method. (2009)
  • Author(s): Sera, K., Terasaki, K., Sasaki, T., Goto, S., Saitoh, Y. and Itoh, J.
  • Journal Title: Int' l Journal of PIXE Volume: Vol.19-1, 2 Pages: 17-27
  • Peer Reviewed
• [Journal Article] Quantitative analysis of very small quantity of organs taken from patients and experimental animals ; standard-free method for organ samples (2008)
  • Author(s): Sera, K., Itoh, J., Goto, S., Saitoh, Y., Fujimura, A., Nosaka, Y., Noda, Y., Nishizuka, S. and Wakabayashi, G.
  • Journal Title: Int' l Journal of PIXE Volume: 18-3, 4 Pages: 111-122
  • Peer Reviewed
• [Presentation] ^<18> F-Choline PETによる口腔癌の診断 (2011)
  • Author(s): 原康文、杉山芳樹、星秀樹、熊谷章子、飯島伸、松本直子
  • Organizer: 第29回日本口腔腫瘍学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2011-01-27
• [Presentation] ^<18> F-Choline PET検査で脳腫瘍が発見された前立腺癌下顎骨転移の1例 (2009)
  • Author(s): 原康文、古屋出、熊谷章子、寺崎一典、星秀樹、小豆島正典、杉山芳樹
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-09
• [Presentation] A patient with drug-induced oral lichen planus who had autoantibody in peripheral blood (2009)
  • Author(s): Kumagai, A., Matsuo, S., Furuuchi, H., Hoshi, H. and Sugiyama, Y.
  • Organizer: The 19th International Conference on Oral and Maxillofacial Surgery
  • Place of Presentation: Shanghai(China)
  • Year and Date: 2009-05-25
• [Presentation] FDG-PETを用いたがん検診で発見された口腔良性腫瘍の2例 (2008)
  • Author(s): 松本直子、飯島伸、熊谷章子、星秀樹、小豆島正典、杉山芳樹
  • Organizer: 第53回日本口腔外科学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-20
• [Remarks]
  • URL: http://www-os2.iwate-med.ac.jp/research.html