2010 Fiscal Year Final Research Report
Studies of aphthous stomatitis on the response to glucocorticoids or immunocompetence of γδT cells.
| Project/Area Number |
20592343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
KOBAYASHI Akio Saitama Medical University, 医学部, 准教授 (60129153)
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| Co-Investigator(Kenkyū-buntansha) |
ABE Takahiro 埼玉医科大学, 医学部, 助教 (20383250)
SATO Tuyoshi 埼玉医科大学, 医学部, 助教 (60406494)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アフタ / ストレス / 糖質コルチコイド / クロモグラニンA / γδTCR |
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| Research Abstract |
The mechanism of onset of aphtha has not been well-elucidated, and diagnosis of aphtha is based entirely on current medical history and clinical findings. As a result, no objective guidelines that serve as the basis of diagnosis are currently available. No fundamental treatments have been established, and only palliative care is given at present. In the present study, we investigated the roles of stress and immune mechanisms, which are known to be causes of aphthous stomatitis. Measurement of salivary stress markers revealed the possibility that these markers vary depending on the sensitivity of the individual to stomatitis. The results indicated the possibility that clock genes in immunocytes are inducibly expressed in response to glucocorticoids (GC), and that γδT cells have immunocompetence. In addition, the circadian rhythm was found to be directly influenced by stress signals. The above findings suggest that onset of aphtha may be related to variations in GC caused by stress and abnormalities in circadian rhythm.
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[Journal Article] Preliminary results of a study comparing conventional radiography with phase-contrast radiography for assessing root morphology of mandibular third molars.2010
Author(s)
Sato T, Nakamoto N, Abe T, Fukushima Y, Tomaru Y, Sakata Y, Nakazawa M, Nakamoto A, Kawasaki H, Wada Y, Ohara H, Araki R, Tanaka J, Yoda T.
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Journal Title
Dentomaxillofac Radiol in press
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[Journal Article] Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts.2010
Author(s)
Sato T, Abe T, Chida D, Nakamoto N, Hori N, Kokabu S, Sakata Y, Tomaru Y, Iwata T, Usui M, Akio K, Yoda T.
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Journal Title
FEBSLetters 584
Pages: 817-824
Peer Reviewed
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[Journal Article] IgG4-related sclerosing sialadenitis : Report of 2 cases and review of the literature.2009
Author(s)
Abe T, Sato T, Tomaru Y, Sakata Y, Kokabu S, Hori N, Kobayashi A, Yoda T.
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Journal Title
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 108(4)
Pages: 544-550
Peer Reviewed
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