2010 Fiscal Year Final Research Report
Study of osteogenic regeneration using dental follicle cells
| Project/Area Number |
20592347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
OGURA Naomi Nihon University, 松戸歯学部, 講師 (10152448)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Ko 日本大学, 松戸歯学部, 助手 (20419758)
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| Research Collaborator |
KONDOH Toshirou 日本大学, 松戸歯学部, 教授 (70178416)
KAMINO Yoshikazu 日本大学, 松戸歯学部, 准教授 (60287662)
AONUMA Haruna 日本大学, 松戸歯学部, 助手(専任扱) (90548306)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 歯嚢由来細胞 / 未分化間葉系幹細胞 / マイクロアレイ解析 / 石灰化能 / 骨芽細胞分化能 / 骨再生医療応用 / シグナリングパスウェイ解析 |
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| Research Abstract |
Dental follicle (DFC), which is an ectomesenchymal tissue surrounding the developing tooth germ, contains stem cells and lineage committed progenitor or precursor cells of osteoblasts. In this study, we compared characteristics of DFC and bone marrow mesenchymal stem cells, and analyzed gene expression profiles. DFC are suggested a major source of stem cells in adults, and have great potential for regenerative purposes in cell therapy.
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