Molecular mechanism of cyto-differentiation of proliferating bone resorping lesions

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592349
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Matsumoto Dental University
• Principal Investigator: KAWAKAMI Toshiyuki Matsumoto Dental University, 大学院・歯学独立研究科, 教授 (80104892)
• Co-Investigator(Kenkyū-buntansha): KEISUKE Nakano 松本歯科大学, 歯学部, 准教授 (10325095) ; NAGATSUKA Hitoshi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70237535)
• Project Period (FY): 2008 – 2010
• Keywords: 口腔外科学一般

Research Abstract

We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In summary, the results showed that these morphogenesis regulation Notch and related factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratio was frequently positive, and was nearly the same between the varied histopathological, cytological patterns; however, the less-differentiated cells were slightly fewer in number that that of well-differentiated cells.

Research Products

• [Journal Article] An unsuspected ameloblastoma in the subpontic region of the mandible with consideration of pathogenesis from the radiographic course. (2010)
  • Author(s): Siar CH, Nakano K, Chelvanayagam PI, Ng KH, Nagatsuka H, Kawakami T
  • Journal Title: Eur J Med Res 15(Peerreviewed) Pages: 153-158
• [Journal Article] Squamous odontogenic tumor of the mandible : A case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1, 2 and Deltal. (2010)
  • Author(s): Siar CH, Nakano K, Ng KH, Tomida M, Nagatsuka H, Kawakami T
  • Journal Title: Eur J Med Res 15(Peerreviewed) Pages: 180-184
• [Journal Article] Notch4 overexpression in ameloblastoma correlates with the solid/multicystic phenotype. (2010)
  • Author(s): Siar CH, Nagatsuka H, Chuah KS, Rivera RS, Nakano K, Ng KH, Kawakami T
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110(Peerreviewd) Pages: 224-233
• [Journal Article] Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma. (2010)
  • Author(s): Siar CH, Nakano K, Han PP, Nagatsuka H, Ng KH, Kawakami T
  • Journal Title: J Oral Pathol Med 39(Peerreviewed) Pages: 552-558
• [Journal Article] Immunolocalization of Notch signaling protein molecules in a maxillary chondrosarcoma and its recurrent tumor. (2010)
  • Author(s): Siar CH, Ha KO, Aung LO, Nakano K, Tsujigiwa H, Nagatsuka H, Ng KH, Kawakami T
  • Journal Title: Eur J Med Res 15(Peerreviewed) Pages: 456-460
• [Journal Article] Immunohistochemical observation of Notch signaling in a case of calcifying cystic odontogenic tumor. (2010)
  • Author(s): Nakano K, Siar CH, Tomida M, Matsuura S, Tsujigiwa H, Nagatsuka H, Kawakani T
  • Journal Title: J Hard Tissue Biol 19(Peerreviewed) Pages: 147-152
• [Journal Article] Immunohistochemical study of Notch signaling proteins in the calcifying epithelial odontogenic tumor (Pindborg tumor). (2010)
  • Author(s): Siar CH, Chuah KS, Nakano K, Rivera RS, Tsujigiwa H, Nagatsuka H, Ng KH, Kawakami T
  • Journal Title: J Hard Tissue Biol 19(Peerreviewed) Pages: 167-174
• [Journal Article] Heparanase and its related molecules in odontogenic tumors. (2009)
  • Author(s): Nagatsuka H, Katase N, Han PP, Tsujigiwa H, Siar CH, Nakajima M, Naomoto Y, Tamamura R, Kawakami T, Gunduz M
  • Journal Title: Oral Med Pathol 13(Peerreviewed) Pages: 81-89
• [Journal Article] Angiogenic squamous dysplasia-like phenomenon in oral epithelial precursor lesions. (2009)
  • Author(s): Siar CH, Oo VPA, Nagatsuka H, Nakano K, Ng KH, Kawakami T
  • Journal Title: Eur J Med Res 14(Peerreviewed) Pages: 315-319
• [Journal Article] Wingless-type protein-1 (Wnt-1) expression in primary conventional and unicystic ameloblastomas and their recurrent tumors. (2009)
  • Author(s): Chuah KS, Siar CH, Nakano K, Nagatsuka H, Khoo SP, Ng KH, Kawakami T
  • Journal Title: J Hard Tissue Biol 18(Peerreviewed) Pages: 63-70
• [Journal Article] A study of recurrent giant odontogenic myxoma of the mandible with immunohistochemical examination of Notch. (2008)
  • Author(s): Nakano K, Chelvanayagam P, Born K, Siar CH, Ng KH, Nagatsuka H, Kawakami T
  • Journal Title: Oral Med Pathol 12(Peerreviewed) Pages: 53-56
• [Journal Article] Notch signaling in benign and malignant ameloblastic neoplasms. (2008)
  • Author(s): Nakano K, Siar CH, Tsujigiwa H, Nagatsuka H, Nagai N, Kawakami T
  • Journal Title: Eur J Med Res 13(Peerreviewed) Pages: 476-480
• [Journal Article] Juxta-epithelial hyalini-zation inhibits tumor growth and invasion in ameloblastoma. (2008)
  • Author(s): Sathi GS, Fujii M, Tmamura R, Borkosky SS, Katase N, Kawakami T, Nagatuska H, Nagai N
  • Journal Title: J Hard Tissue Biol 17(2)(Peerreviewed) Pages: 63-68
• [Journal Article] Immunohistochemical character-ristics of odontogenic neoplasms and their physiological counterparts. (2008)
  • Author(s): Nakano K, Nagatsuka H, Tsujigiwa H, Gunduz M, Katase N, Siar CH, Kawakami T
  • Journal Title: J Hard Tissue Biol 17(3)(Peerreviewed) Pages: 79-90
• [Presentation] Immunohistchemical expression of Notch signaling in calcifying cystic odontogenic tumor (2010)
  • Author(s): Kawakami T, Siar CH, Nakano K, Tomida M, Matsuura S, Tsujigiwa H, Nagatsuka H
  • Organizer: Biennial Conference of European Association of Oral Medicine (10^<th>) Incorporating the World Workshop on Oral Medicine (Oral Dis 16: 517, 2010)
  • Place of Presentation: London
  • Year and Date: 2010-09-25
• [Presentation] Wnt-antagonist sFRP-2 inhibits bone formation and promotes cell proliferation in ameloblastoma (2010)
  • Author(s): Nagatsuka H, Ara SGS, Katase N, Siar CH, Kawakami T, Tamamura R, Hirata Y, Tsujigiwa H
  • Organizer: International Congress of Oral Pathology and Medicine (15^<th>)(Program and Abstract book p88)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-08-17
• [Presentation] 石灰化嚢胞性歯原性腫瘍の1例-Notchの免疫組織学的検討- (2010)
  • Author(s): 中野敬介,辻極秀次,長塚仁,長谷川博雅,川上敏行
  • Organizer: 日本臨床口腔病理学会総会(第21回)(プログラム・抄録集 p133)
  • Place of Presentation: 大阪
  • Year and Date: 2010-07-31
• [Presentation] Notch expression patterns and ameloblastoma phenotypes (2010)
  • Author(s): Siar CH, Nakano K, Chuah KS, Nagatsuka H, Ng KH, Kawakami T
  • Organizer: International Association for Dental Research (88^<th>) (J Dent Res 89 (Sp Iss B) Abstract No. 3478, 2010)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-15
• [Presentation] Squamous odontogenic tumorの1症例:Notchとその関連因子の検討 (2010)
  • Author(s): 中野敬介,長塚仁,川上敏行
  • Organizer: 日本病理学会総会(第99回)(日病会誌 99 : 313, 2010)
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] Notch receptors and their ligands in ameloblastomas (2009)
  • Author(s): Siar CH, Kawakami T, Nakano K, Nagatsuka H, Ng KH
  • Organizer: 2009 FDI Annual World Dental Congress
  • Place of Presentation: Singapore
  • Year and Date: 2009-09-04
• [Presentation] 口腔粘膜の境界悪性病変におけるデスモゾームタンパク質の異常発現 (2009)
  • Author(s): 相沢聡一,落合隆永,中野敬介,木村晃大,川上敏行,長谷川博雅
  • Organizer: 日本臨床口腔病理学会総会(第20回)(プログラム・抄録集 p86;Oral Med Pathol 14:75, 2009)
  • Place of Presentation: 札幌
  • Year and Date: 2009-07-30
• [Presentation] Malaysian Dental Association Annual Dental Meeting (66^<th>) (2009)
  • Author(s): Siar CH, Ng KH, Nagatsuka H, Nakano K, Kawakami T
  • Organizer: Notch signaling molecules in ameloblastoma
  • Place of Presentation: Penang, Malaysia
  • Year and Date: 2009-06-10
• [Presentation] Ameloblastomaとameloblastic carcinomaにおけるHSP27の発現 (2009)
  • Author(s): 中野敬介,川上敏行
  • Organizer: 日本病理学会総会(第98回)(日病会誌 98:360, 2009)
  • Place of Presentation: 京都
  • Year and Date: 2009-05-03
• [Presentation] 歯胚およびその新生物における基底膜の構造変化とその意義 (2008)
  • Author(s): 中野敬介,長塚仁,永井教之,川上敏行
  • Organizer: 日本歯科医学会総会(第21回)(日歯会誌61:111, 2008)
  • Place of Presentation: 横浜
  • Year and Date: 2008-11-14
• [Presentation] Recurrent giant odontogenic myxoma of the mandible (2008)
  • Author(s): Kawakami T, Nakano K, Chelvanayagam P, Born K, Siar CH, Ng KH
  • Organizer: International congress of oral pathology and medicine (International association of oral pathologists 14^<th>, American academy of oral & maxillofacial pathology 62^<nd>)(Program and abstract p23)
  • Place of Presentation: San Francisco
  • Year and Date: 2008-06-23
• [Presentation] AmeloblastomaとAmeloblastic CarcinomaにおけるNotchの発現 (2008)
  • Author(s): 中野敬介,長塚仁,永井教之,川上敏行
  • Organizer: 日本病理学会総会(第97回)(日病会誌 97:75, 2008)
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-16
• [Book] Cell differentiation of neoplastic cells originating in the oral and craniofacial regions (New York, USA.) (2009)
  • Author(s): Kawakami T, Nagatsuka H
  • Publisher: Nova Science Publishers
• [Book] Cell differentiation research developments(in Ivanova LB Ed) (Chapter1 : Cell differentiation of neoplastic cells originating in the oral and craniofacial regions) (New York, USA) (2008)
  • Author(s): Kawakami T, Nagatsuka H, Nakano K, Shimizu T, Tsujigiwa H, Hasegawa H, Nagai N
  • Total Pages: 1-30
  • Publisher: Nova Science Publishers