2010 Fiscal Year Final Research Report
Establishment of Immunotherapy for oral cancer : antitumor effect of OK432-conjugated tumor vaccine on mouse cancer model
| Project/Area Number |
20592350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
LI Xianqi Matsumoto Dental University, 総合歯科医学研究所, 講師 (60350831)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Miho 松本歯科大学, 歯学部, 助教 (00444795)
NIWA Takashi 松本歯科大学, 歯学部, 助手 (60507680)
NAKAZAWA Takashi 松本歯科大学, 歯学部, 助手 (50582368)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 腫瘍ワクチン / OK-432 / サイトカイン / 腫瘍免疫療法 |
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| Research Abstract |
Squamous cell cancer cell line (KLN-205 cells) was mixed with OK-432 serviced as OK-432 vaccine. In this research, we used OK-432 vaccine to clarify the mechanisms of antitumor in murine tongue cancer model. The result showed that OK-432 could induce Th1 cytokine production, activated cytotoxic T lymphocyte and macrophage. It is also clear that OK-432 induced strong an antitumor immune response.
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Research Products
(17 results)
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[Journal Article] Bone formation without lamina dura in the middle-aged and elderly : possible dependence on enamel.2010
Author(s)
Yamaoka M, Ishizuka M, Ishihama K, Takahashi M, Takahashi M, Yamada H, Teramoto Y, Yasuda K, Shiba T, Uematsu T, Furusawa K
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Journal Title
Clin Interv Aging 5
Pages: 37-43
Peer Reviewed
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[Journal Article] Inorganic polyphosphate induces osteoblastic differentiation.2010
Author(s)
Usui Y, Uematsu T, Uchihashi T, Takahashi M, Takahashi M, Ishizuka M, Doto R, Tanaka H, Komazaki Y, Osawa M, Yamada K, Yamaoka M, Furusawa K
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Journal Title
J Dent Res 89
Pages: 504-509
Peer Reviewed
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