2010 Fiscal Year Final Research Report
Study on effects of endocrine disrupter on cleft lip and/or palate.
| Project/Area Number |
20592352
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Aichi Gakuin University |
|---|
Principal Investigator |
NIIMI Teruyuki Aichi Gakuin University, 歯学部, 講師 (60291762)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NATSUME Nagato 愛知学院大学, 歯学部, 教授 (90183532)
MINAMI Katsuhiro 愛知学院大学, 歯学部, 講師 (70346162)
INOUE Makoto 愛知学院大学, 薬学部, 教授 (50191888)
SASAKI Takuma 愛知学院大学, 薬学部, 教授 (90109976)
TANAKA Motohiro 愛知学院大学, 薬学部, 准教授 (60197481)
TANABE Hiroki 愛知学院大学, 薬学部, 講師
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | ビスフェノールA / 口唇裂 / 先天異常 / 予防 / 胸腺 |
|---|
| Research Abstract |
As an environmental factor, the inhibition of the production of urokinase-type plasminogen activator (u-PA) as a marker of vascular development was studied using bisphenol A (BPA). The u-PA production was not inhibited by BPA. On the other hand, the metabolism of folate affects the cause of cleft lip and/or palate. To clarify this point, several gene expressions related with folate metabolism were determined.
It is suggested that BPA is likely to partly modulate the transcription of the genes involved in bone metabolism through retinoic acid receptor, resulting in the suppression of the development of a cleft lip and/or palate. Further, through the comprehensive screening of natural retinoic acid receptor or estrogen receptor agonists to prevent the development of a cleft lip and/or palate, we isolated a few RAR agonists from crude drugs used in Kampo medicines.
|
