2010 Fiscal Year Final Research Report
Type of bone invasion in human or al squamous cell carcinoma and its mechanisms ; application for molecular diagnosis
| Project/Area Number |
20592356
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | University of Toyama |
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Principal Investigator |
NOGUCHI Makoto University of Toyama, 大学院・医学薬学研究部(医学), 教授 (50208328)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Naoya 富山大学, 大学院・医学薬学研究部(医学), 准教授 (80323723)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 口腔扁平上皮癌 / 顎骨浸潤 / 破骨細胞 / 破骨細胞分化誘導因子 / ビスホスホネート製剤 / アポトーシス |
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| Research Abstract |
We immunohistochemically observed expression of various kinds of cytokines related to osteoclastic differentiation in human squamous cell carcioma of the lower gum. Over-expression of RANKL or OPG could be barely seen in cancer cells, although PTHrP was slightly expressed. The relationship between type of bone invasion and expression of them has failed to clarify.
Using oral squamous cancer cell lines, over-expression of MMP9 or periostin was strongly observed in high invasive cell line (HSC4) compared with low invasive cell line (HSC3). Apoptosis was induced in HSC4 cells with low dose bisphosphonate. Moreover, induction of apoptosis in cell line was enhanced by addition to Ca.
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