2010 Fiscal Year Final Research Report
Development research into molecular diagnosis and treatment method of carcinoma of the oral cavity targeting WNT signal system transfer factor group
| Project/Area Number |
20592360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KOIZUMI Koichi Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (30335682)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Tetsuji 広島大学, 大学院・医歯薬学総合研究科, 教授 (00169153)
KANDA Taku 広島大学, 病院, 助教 (00423369)
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| Project Period (FY) |
2008 – 2010
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| Keywords | WNT / β-カテニン / 口腔癌 |
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| Research Abstract |
Oncogene β-katenin that was one of the Wnt signal system transfer factors had both the one to show the irregular accumulation to the cytoplasm and the nucleus in the culture oral carcinoma cell and the one not so. Moreover, the one in the part phosphorylated by GSK3 of β-katenin with the gene mutation and the one that not was existed in the cell that had abnormally accumulated β-katenin in the cytoplasm and the nucleus. Abnormal accumulation of β-katenin and the correlativity of the condition and the prognosis are being examined now.
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