麻酔薬の機序的膜作用の再検証 : 生体膜ラフトならびに特異的膜脂質との相互作用

Products Report

• Project/Area Number: 20592381
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Asahi University
• Principal Investigator: TSUCHIYA Hironori Asahi University, 歯学部, 教授 (30131113)
• Co-Investigator(Kenkyū-buntansha): MIZOGAMI Maki 朝日大学, 歯学部, 准教授 (10231614)
• Project Period (FY): 2008 – 2010

Research Products

• [Journal Article] Stereostructure-based differences in the interactions of cardiotoxic local anesthetics with cholesterol-containing biomimetic membranes (2011)
  • Author(s): Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: (in press)
  • Peer Reviewed
• [Journal Article] Do local anesthetics interact preferentially with membrane lipid rafts? Comparative interactivities with raft-like membranes (2010)
  • Author(s): Hironori Tsuchiya・Takahiro Ueno・Maki Mizogami・Ko Takakura
  • Journal Title: Journal of Anesthesia Volume: 24 Pages: 639-642
  • Peer Reviewed
• [Journal Article] The interactivities with lipid membranes differentially characterize selective and nonselective β_1-blockers (2010)
  • Author(s): Maki Mizogami, Ko Takakura, Hironori Tsuchiva
  • Journal Title: European Journal of Anaesthesiology Volume: 27 Pages: 829-834
  • Peer Reviewed
• [Journal Article] Comparative effects of β-carbolines on platelet aggregation and lipid membranes (2010)
  • Author(s): Hironori Tsuchiya, Shuichi Ohmoto
  • Journal Title: Pharmacological Reports Volume: 62 Pages: 689-695
  • Peer Reviewed
• [Journal Article] Local anesthetics structure-dependently interact with anionic phospholipid membranes to modify the fluidity (2010)
  • Author(s): Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami, Ko Takakura
  • Journal Title: Chemico-Biological Interactions Volume: 183 Pages: 19-24
  • Peer Reviewed
• [Journal Article] Comparative study on determination of antioxidant and membrane activities of propofol and its related compounds (2010)
  • Author(s): Hironori Tsuchiya, Takahiro Ueno, Toshiyuki Tanaka, Nobuyasu Matsuura, Maki Mizogami
  • Journal Title: European Journal of Pharmaceutical Sciences Volume: 39 Pages: 97-102
  • Peer Reviewed
• [Journal Article] Membrane interactivity of charged local anesthetic derivative and stereoselectivity in membrane interaction of local anesthetic enantiomers (2008)
  • Author(s): Hironori Tsuchiya, Maki Mizogami
  • Journal Title: Local and Regional Anesthesia Volume: 1 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Stereospecific Interaction of Bupivacaine Enantiomers with Lipid Membranes (2008)
  • Author(s): Maki Mizogami, Hironori Tsuchiya, Takahiro Ueno, Masanori Kashimata, and Ko Takakura
  • Journal Title: Regional Anesthesia and Pain Medicine Volume: 33 Pages: 304-311
  • Peer Reviewed
• [Journal Article] Local anesthetic failure associated with inflammation : verification of the acidosis mechanism and the hypothetic participation of inflammatory peroxynitrite (2008)
  • Author(s): Takahiro Ueno, Hironori Tsuchiya, Maki Mizogami, Ko Takakura
  • Journal Title: Journal of Inflammation Research Volume: 1 Pages: 41-48
  • Peer Reviewed
• [Journal Article] Membrane effect of lidocaine is inhibited by interaction with peroxynitrite (2008)
  • Author(s): TAKAHIRO UENO, MAKI MIZOGAMI, KO TAKAKURA, and HIRONORI TSUCHIYA
  • Journal Title: Journal of Anesthesia Volume: 22 Pages: 96-99
  • Peer Reviewed
• [Journal Article] Peroxynitrite affects lidocaine by acting on membrane-constituting lipids (2008)
  • Author(s): TAKAHIRO UENO, MAKI MIZOGAMI, KO TAKAKURA, and HIRONORI TSUCHIYA
  • Journal Title: Journal of Anesthesia Volume: 22 Pages: 475-478
  • Peer Reviewed
• [Journal Article] Antioxidant Activity Analysis by Liposomal Membrane System and Application to Anesthetics (2008)
  • Author(s): Hironori TSUCHIYA, Takahiro UENO, Maki MIZOGAMI, and Ko TAKAKURA
  • Journal Title: Analytical Sciences Volume: 24 Pages: 1557-1562
  • Peer Reviewed
• [Journal Article] Anesthetic and Cardiotoxic Effects in the Light of the Interactions of Local Anesthetics and Membrane Lipids (2008)
  • Author(s): Takahiro Ueno, Maki Mizogami, Ko Takakura and Hironori Tsuchiya
  • Journal Title: Journal of the Pharmaceutical Society of Japan Volume: 128(Suppl.2) Pages: 33-34
  • Peer Reviewed
• [Presentation] POTENTIAL ANTIOXIDANT UTILITY OF PROPOFOL BEYOND ANESTHESIA ASSOCIATED WITH MEMBRANE INTERACTION : STRUCTURE-ACTIVITY RELATIONSHIP (2011)
  • Author(s): H.Tsuchiya, T.Ueno, M.Mizogami
  • Organizer: 3^<rd> World Congress of Total Intravenous Anaesthesia & Target Controlled Infusion
  • Place of Presentation: Singapore
  • Year and Date: 2011-04-02
• [Presentation] STEREOSTRUCTURE-MEMBRANE INTERACTIVITY RELATIONSHIP OF LOCAL ANAESTHETICS ASSOCIATED WITH THEIR STEREOSELECTIVE CARDIOTOXICITY (2010)
  • Author(s): Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami, Ko Takakura
  • Organizer: 21^<st> International Symposium on Medicinal Chemistry
  • Place of Presentation: Brussels
  • Year and Date: 2010-09-06
• [Presentation] 膜脂質との相互作用に基づく選択的/非選択的β1遮断薬の識別 (2010)
  • Author(s): 溝上真樹, 東康加, 家始聡介, 高倉康, 土屋博紀
  • Organizer: 日本麻酔科学会東海・北陸支部第8回学術集会
  • Place of Presentation: 福井
  • Year and Date: 2010-09-04
• [Presentation] 局所麻酔薬の立体構造に選択的な心毒性の仮説的機序:ブピバカインならびにロピバカインの立体異性体間で異なるコレステロール生体膜との相互作用 (2010)
  • Author(s): 溝上真樹,上野高広,藤原茂樹,高倉康,土屋博紀
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-03
• [Presentation] STRUCTURE-DEPENDENT MEMBRANE INTERACTION OF LOCAL ANESTHETICS : A MECHANISTIC CLUE FOR THEIR STRUCTURE-SELECTIVE CARDIOTOXICITY (2010)
  • Author(s): Hironori Tsuchiya, Takahiro Ueno
  • Organizer: NYSORA World Anesthesia Congress
  • Place of Presentation: Dubai
  • Year and Date: 2010-03-07
• [Presentation] Local anaesthesia affected by inflammation : the conventional mechanism based on tissue acidosis and the novel mechanism focused on inflammatory peroxynitrite (2009)
  • Author(s): Maki Mizogami, Takahiro Ueno, Ko Takakura, Hironori Tsuchiya
  • Organizer: 12^<th> International Dental Congress on Modern Pain Control
  • Place of Presentation: Gold Coast
  • Year and Date: 2009-10-17
• [Presentation] 局所麻酔薬の構造依存的心毒性に関するカルジオリピンに着目した機序的膜脂質相互作用 (2009)
  • Author(s): 上野高広,溝上真樹,藤原茂樹,高倉康,土屋博紀
  • Organizer: 日本麻酔科学会第56回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2009-08-16
• [Presentation] Membrane lipids as one of drug targets : Stereostructure-dependent membrane interactions of local anesthetics relevant to their cardiotoxicity (2009)
  • Author(s): Hironori Tsuchiya and Takahiro Ueno
  • Organizer: 42^<nd>IUPAC Congress
  • Place of Presentation: Glasgow
  • Year and Date: 2009-08-04
• [Presentation] MECHANISTIC MEMBRANE-INTERACTION OF LOCAL ANAESTHETICS FOR THEIR STRUCTURE-DEPENDENT CARDIOTOXIC EFFECTS (2008)
  • Author(s): Hironori Tsuchiya
  • Organizer: Hong Kong Academy of Medicine 15^<th> Anniversary Congress
  • Place of Presentation: Hong Kong
  • Year and Date: 2008-11-15
• [Presentation] 局所麻酔薬と膜脂質の相互作用からみた麻酔効果と心毒性 (2008)
  • Author(s): 上野高広,溝上真樹,高倉康,土屋博紀
  • Organizer: 第30回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2008-08-07