2010 Fiscal Year Final Research Report
Reverification of the mechanistic membrane effects of anesthetics : Interactions with biomembrane rafts and specific membrane lipids
| Project/Area Number |
20592381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
TSUCHIYA Hironori Asahi University, 歯学部, 教授 (30131113)
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| Co-Investigator(Kenkyū-buntansha) |
MIZOGAMI Maki 朝日大学, 歯学部, 准教授 (10231614)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 麻酔薬 / 作用機序 / 生体膜 / 相互作用 / ラフト / 膜脂質 / 膜流動性 / 心毒性 |
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| Research Abstract |
Apart from the conventional mechanism in which anesthetics specifically bind to receptors and channels, we reverified the mechanistic hypothesis that anesthetics may interact with biomembranes to exert clinically useful and adverse effects based on the latest structural and functional theory about biomembranes. The relevance of membrane lipid rafts to anesthetics was questionable at least in their effects on raft-like model membranes. However, anesthetics structure-dependently interacted with biomimetic membranes consisting of specific lipids (cholesterol and anionic phospholipids) and their interacting potencies were discriminated even between stereoisomers. These results support the membrane interaction of anesthetics as the mode of action.
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