2010 Fiscal Year Final Research Report
The elucidation of Bone Remodeling Change of EPH/ephrin signal with the Aging
| Project/Area Number |
20592389
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
KOIKE Mariko Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (50376779)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Yoshiro 東京医科歯科大学, 医歯学総合研究科, 講師 (20292980)
KANEKO Sawa 東京医科歯科大学, 医歯学総合研究科, 助教 (80372449)
HOSOMICHI Jyun 東京医科歯科大学, 医歯学総合研究科, 助教 (00420258)
WATARI Ippei 東京医科歯科大学, 医歯学総合研究科, 助教 (10431941)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 老化 / 骨リモデリング / 歯周組織 |
|---|
| Research Abstract |
The changes in periodontal tissue with growth and aging were analyzed. The expression of CGRP-ir nerve fibers in the PDL is most active in the growth period and decreases gradually with aging. Moreover, age-related decreases in the expression of bFGF may delay the regeneration of the periodontal ligament. Such an effect may act unfavorably in the case of tooth movement.
|
