2010 Fiscal Year Final Research Report
Analysis of mutans streptococci signal transduction system in biofilm formation
| Project/Area Number |
20592399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
NAKANO Michiyo Osaka University, 大学院・歯学研究科, 准教授 (30359848)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ミュータンスレンサ球菌 / Streptococcus mutans / う蝕 / シグナル伝達システム / 遺伝子 |
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| Research Abstract |
Quorum sensing has been reported to mediate biofilm formation by Streptococcus mutans. Recombinase A (RecA) encoded by the recA gene, is essential for transformation of both plasmids and chromosomal DNA. We found that the expression intensity of glucosyltransferases was reduced and biofilm structure altered in an RecA-deficient mutant strain. Thus, RecA was shown to have strong relationships with biofilm formation and quorum sensing.
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