2010 Fiscal Year Final Research Report
Analysis of mechanism in reducing pain during orthodontic tooth movement by CO_2 laser
| Project/Area Number |
20592401
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
DEGUCHI Toru 東北大学, 大学院・歯学研究科, 准教授 (30346457)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 歯の移動 / 神経ペプチド / レーザー / 三次元形態計測 |
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| Research Abstract |
The aim of this study is to investigate the pain reducing effect and mechanism of CO2 laser during orthodontic tooth movement. In the present study, we analyzed the effect of CO2 laser in the central (medullary dorsal horn)and in the peripheral (tooth pulp, periodontal ligament)nervous system during experimental tooth movement in rats. As a result, increased c-fos known as the pain marker, was observed after experimental tooth movement, and it significantly decreased at the medullary dorsal horn after CO2 laser irradiation. On the other hand, there was no significant change in the calcitonin gene-related peptide (CGRP)and PGP9. 5 at the tooth pulp and periodontal ligament after the irradiation of CO2 laser. Furthermore, by the temperature measurements, the maximum temperatures were less than 40°C, which cannot cause tissue injury. Therefore, it is suggested that the CO2 laser reduces pain during experimental tooth movement by inhibiting c-fos neurons at the central nervous system without damaging peripheral tissue.
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[Presentation] 側貌骨格形態と顎運動機能の関連性について2008
Author(s)
Kataoka T, Hashimoto T, Deguchi T, Shiraga N, Imai M, Minato M, Takano-Yamamoto T, Yamashiro T
Organizer
第67回日本矯正歯科学会大会
Place of Presentation
千葉
Year and Date
20080916-18
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