2010 Fiscal Year Final Research Report
Functional analysis of periostin -anti-apoptotic action of periostin in osteoblasts and periodontal ligament cells
| Project/Area Number |
20592404
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
FUJIHARA Shinji The University of Tokushima, 病院, 助教 (70403706)
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| Co-Investigator(Kenkyū-buntansha) |
HORIUCHI Shinya 徳島大学, 病院, 助教 (70263861)
IZAWA Takashi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (30380017)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 歯学 / ペリオスチン / アポトーシス / シグナル伝達 |
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| Research Abstract |
In this study, we examined the effect of periostin on the function of osteoblasts and periodontal ligament cells, such as apoptosis and the associated signal pathway. In the result, it is revealed that periostin is associated with the apoptosis of periodontal ligament cells by the hypoxia-induced system, and the signaling pathway including FAK, JNK, ERK, P38 and AKT. Additionally, in the signaling pathway of β-catenin, periostin might affect the anti-apoptotic action in various cells.
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