2010 Fiscal Year Final Research Report
Role of Ten-m/Odz3 in the formation, growth and functional maintenance of mandibular condylar cartilage
| Project/Area Number |
20592408
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
FUKUNAGA Tomohiro Kagoshima University, 病院, 講師 (70362994)
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHITA Nobuo 東北大学, 大学院・歯学研究科, 助教 (50431515)
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| Project Period (FY) |
2008 – 2010
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| Keywords | マウス下顎頭軟骨 / Ten-m / Odz3 / 細胞分化 / 遺伝子発現 |
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| Research Abstract |
The mandibular condyle has been speculated to develop via the differentiation of the fibroblast-like cells covering the condyle into chondrocytes ; however, the developmental mechanisms behind this process have not been revealed. We describe the temporal and spatial expression of Ten-m/Odz3 mRNA as determined by in situ hybridization in mouse mandibular condylar cartilage of 1 day, 1 week, and 3 week of age during the early stages of development. Ten-m/Odz3 was expressed in the fibrous layer and the proliferating and mature chondrocyte layers, but was not detected in the hypertrophic chondrocyte layer. Furthermore, we evaluated the in vitro expression of Ten-m/Odz3 using ATDC5 cells, a mouse chondrogenic cell line. Ten-m/Odz3 was expressed during the early stage of the differentiation of mesenchymal cells into chondrocytes. These findings suggest that Ten-m/Odz3 is involved in the differentiation of chondrocytes and that it acts as a regulatory factor in the early stages of the development of mandibular condylar cartilage.
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[Journal Article] Sox9 expression during fracture repair.2011
Author(s)
Shintaku Y, Murakami T, Yanagita T, Kawanabe N, Fukunaga T, Matsuzaki K, Uematsu S, Yoshida Y, Kamioka H, Takano-Yamamoto T, Takada K, Yamashiro T
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Journal Title
Cells Tissues Organs (印刷中)
Peer Reviewed
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