2010 Fiscal Year Final Research Report

Clarification of the role of prostaglandins in drug-induced stomatitis and establishment of a new oral care

Research Project

Project/Area Number	20592416
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Orthodontic/Pediatric dentistry
Research Institution	The Nippon Dental University
Principal Investigator	KAWAKAMI Tomomi The Nippon Dental University, 生命歯学部, 講師 (30277595)
Co-Investigator(Kenkyū-buntansha)	KARIBE Hiroyuki 日本歯科大学, 生命歯学部, 教授 (50234000) OGATA Kiyokazu 日本歯科大学, 生命歯学部, 准教授 (90257006)
Project Period (FY)	2008 – 2010
Keywords	小児 / 悪性腫瘍 / 口内炎 / プロスタグランジン / シクロフォスファミド
Research Abstract	The aim of this study was to investigate the effect of cyclophosphamide on tongue epithelium and periodontal tissue in growing mice. In the treatment group the root formation was inhibited and the periodontal ligament cells were less observed compared to the control group. Structural changes in the tongue epithelium were less than the changes in periodontal tissue except high-dose group. These results suggest that the changes in periodontal tissue by cyclophosphamide affects to masticatory function as a supporting organization.

(1 results)