Tongue position controller as an alternative treatment for obstructive sleep apnoea

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592422
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Neuropsychiatric Research Institute
• Principal Investigator: TSUIKI Satoru Neuropsychiatric Research Institute, 研究部, 研究員 (90376765)
• Co-Investigator(Kenkyū-buntansha): INOUE Yuichi 財団法人神経研究所, 研究部, センター長 (50213179) ; SUGIURA Tatsuki 財団法人神経研究所, 研究部, 研究員 (30378202) ; SASAI Taeko 財団法人神経研究所, 研究部, 研究員 (70412096)
• Co-Investigator(Renkei-kenkyūsha): ISONO Shiroh 千葉大学, 医学研究科, 准教授 (80212968) ; MAEDA Keiko 財団法人神経研究所, 研究部, 研究員 (30529938)
• Project Period (FY): 2008 – 2010
• Keywords: 睡眠時無呼吸症候群 / 舌位置制御装置 / 口腔内装置 / CPAP

Research Abstract

The sleep-related reduction in upper airway muscle activity precipitates tongue collapse and leads to Obstructive Sleep Apnoea (OSA). We hypothesize that OSA could be alleviated if the awake tongue position is maintained during sleep through the use of a newly-developed tongue position controller (TPC). The TPC, which incorporates a closed-loop system where the tongue is held by a custom-made tongue positioner together with continuously-applied negative pressure, improves the severity of OSA and subjective sleepiness. This approach offers a potential alternative for OSA treatment without the application of positive airway pressure and mandibular/tongue advancement.

Research Products

• [Journal Article] Dose-dependent effects of mandibular protrusion on genioglossus activity in sleep apnoea. (2011)
  • Author(s): Almeida F.R., Tsuiki, S. Hattori, Y., Takei, Y., Inoue, Y., Lowe, A.A.
  • Journal Title: Eur Respir J 37 Pages: 209-212
  • Peer Reviewed
• [Journal Article] Excessive daytime sleepiness among Japanese public transportation drivers engaged in shift-work. (2010)
  • Author(s): Asaoka, S., Namba, K., Tsuiki, S., Komada, Y., Inoue, Y.
  • Journal Title: J Occup Environ Med 52 Pages: 813-818
  • Peer Reviewed
• [Journal Article] Differences in clinical characteristics between two subgroups of obstructive sleep apnea syndrome in the elderly- comparison between cases with elderly and middle age onset-. (2010)
  • Author(s): Kobayashi, M., Namba, K., Tsuiki, S., Matsuo, A., Sugiura, T., Inoue, Y.
  • Journal Title: Chest 137 Pages: 1310-1315
  • Peer Reviewed
• [Journal Article] Optimal positive airway pressure predicts oral appliance treatment response to sleep apnoea. (2010)
  • Author(s): Tsuiki, S., Kobayashi, M., Namba, K., Oka, Y., Komada, Y., Kagimura, T., Inoue, Y.
  • Journal Title: Eur Respir J 35 Pages: 1098-1105
  • Peer Reviewed
• [Journal Article] Clinical characteristics of familial obstructive sleep apnea syndrome in Japanese. (2010)
  • Author(s): Matsuo, A., Inoue, Y., Tsuiki, S., Enomoto, M., Chiba, H.
  • Journal Title: Respirology 15 Pages: 93-98
  • Peer Reviewed
• [Journal Article] Motor vehicle accident (MVA) risk factors for drivers with obstructive sleep apnea syndrome (OSAS) in the Tokyo metropolitan area. (2009)
  • Author(s): Komada, Y., Nishida, Y., Namba, K., Tsuiki, S., Abe, T., Inoue, Y.
  • Journal Title: Tohoku Journal of Experimental Medicine 219 Pages: 11-16
  • Peer Reviewed
• [Journal Article] Anatomical balance of the upper airway and obstructive sleep apnea. (2008)
  • Author(s): Tsuiki, S., Isono, S., Ishikawa, T., Yamashiro, Y., Tatsumi, K., Nishino, T.
  • Journal Title: Anesthesiology 108 Pages: 1009-101
  • Peer Reviewed
• [Presentation] Optimal positive airway pressure predicts oral appliance treatment response to sleep apnoea. (2010)
  • Author(s): Tsuiki, S., et al.
  • Organizer: European Respiratory Society 2010
  • Place of Presentation: Barcelona, Spain.
  • Year and Date: 20100918-20100922
• [Presentation] How mandibular advancement modulates genioglossus muscle activity in obstructive sleep apnoea? (2010)
  • Author(s): Almeida F.R., et al.
  • Organizer: European Respiratory Society 2010
  • Place of Presentation: Barcelona, Spain.
  • Year and Date: 20100918-20100920
• [Presentation] Posttreatment objective evaluation of oral appliances for obstructive sleep apnoea. (2010)
  • Author(s): Tsuiki, S., et al.
  • Organizer: 20th Congress of the European Sleep Research Society
  • Place of Presentation: Lisbon, Portugal.
  • Year and Date: 20100914-20100918
• [Presentation] Does dental arch size affect obstructive sleep apnea? (2010)
  • Author(s): Maeda, K., et al.
  • Organizer: International Association for Dental Research General Session
  • Place of Presentation: Barcelona, Spain.
  • Year and Date: 20100714-20100717
• [Presentation] Dose-dependent effects of mandibular protrusion on genioglossal activity in obstructive sleep apnoea. (2010)
  • Author(s): Almeida F.R., et al.
  • Organizer: American Thoracic Society 2010 Louisiana International Conference
  • Place of Presentation: Louisiana.
  • Year and Date: 20100519-20100524
• [Presentation] A comparison of oral appliance efficacy with CPAP in patients with positional-dependent obstructive sleep apnea. (2009)
  • Author(s): Tsuiki, S, et al.
  • Organizer: The 6th Congress of Asian Sleep Research Society, The 34th Annual Meeting of Japanese Society of Sleep Research and The 16th Annual Meeting of Japanese Society for Chronobiology Joint Congress.
  • Place of Presentation: Osaka, Japan.
  • Year and Date: 20091024-20091027
• [Presentation] Can we predict oral appliance treatment response to obstructive sleep apnea based on optimal positive airway pressure? (2009)
  • Author(s): Tsuiki, S, et al.
  • Organizer: American Academy of Dental Sleep Medicine 18th Annual Meeting.
  • Place of Presentation: Seattle, USA.
  • Year and Date: 20090605-20090607
• [Presentation] Tongue size and dental arch changes in obese obstructive sleep apnea patients. (2009)
  • Author(s): Maeda, K., et al.
  • Organizer: American Academy of Dental Sleep Medicine 18th Annual Meeting.
  • Place of Presentation: Seattle, USA.
  • Year and Date: 20090605-20090607
• [Presentation] Mallampati score and obesity as simple predictors of oral appliance efficacy in patients with obstructive sleep apnea. (2008)
  • Author(s): Tsuiki, S., et al.
  • Organizer: 22nd Annual Meeting of the Associated Professional Sleep Societies (APSS 2008)
  • Place of Presentation: Baltimore, Pennsylvania.
  • Year and Date: 20080609-20080614
• [Presentation] The interaction between upper airway configuration and function in obstructive sleep apnea.
  • Author(s): Tsuiki, S.
  • Organizer: World Congress on Sleep Apnea 2009, Seoul, Korea,20090325-20090328
• [Book] 睡眠呼吸障害Update2011 (2011)
  • Author(s): 對木悟, 他
  • Total Pages: 188-194
  • Publisher: ライフ・サイエンス
• [Book] 睡眠時無呼吸症候群-改訂第2版- (2009)
  • Author(s): 對木悟
  • Total Pages: 152-156
  • Publisher: 克誠堂出版
• [Book] 睡眠検査学の基礎と臨床 (2009)
  • Author(s): 對木悟
  • Total Pages: 176-179
  • Publisher: 新興医学出版社
• [Book] 睡眠学 (2009)
  • Author(s): 對木悟
  • Total Pages: 637-639
  • Publisher: 朝倉書店
• [Book] 臨床睡眠学-睡眠障害の基礎・臨床-66巻増刊号2 (2008)
  • Author(s): 對木悟, 他
  • Total Pages: 182-186
  • Publisher: 日本臨床
• [Remarks] なし
• [Patent(Industrial Property Rights)] 舌位置制御装置 (2010)
  • Inventor(s): 對木悟, 南野脩
  • Industrial Property Rights Holder: 對木悟, 南野脩
  • Industrial Property Number: 特許,第4445565号
  • Acquisition Date: 2010-01-22
• [Patent(Industrial Property Rights)] Tongue position controller (2009)
  • Inventor(s): TSUIKI Satoru, MINAMINO Osamu
  • Industrial Property Rights Holder: TSUIKI Satoru, MINAMINO Osamu
  • Industrial Property Number: 特許,PCT/JP2009/051427
  • Filing Date: 2009-01-29