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2010 Fiscal Year Final Research Report

Biologic pathways for the relationship between periodontitis and cardiovascular disease

Research Project

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Project/Area Number 20592426
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionNiigata University

Principal Investigator

TABETA Koichi  Niigata University, 超域研究機構, 准教授 (20401763)

Co-Investigator(Kenkyū-buntansha) 山崎 和久  新潟大学, 医歯学系, 教授 (00182478)
Project Period (FY) 2008 – 2010
Keywords歯周炎 / Porphyromonas gingivalis / エイジング / 動脈硬化症 / マウスモデル
Research Abstract

Periodontal infection itself does not cause atherosclerosis, but it accelerates it by inducing systemic inflammation and deteriorating lipid metabolism, particularly when underlying hyperlipidemia or susceptibility to hyperlipidemia exists, and it may contribute to the development of coronary heart disease. Further study is undertaken related to aging.

  • Research Products

    (7 results)

All 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Chronic Oral Infection with Porphyromonas gingivalis Accelerates Atheroma Formation by Shifting the Lipid Profile.2011

    • Author(s)
      Maekawa T, Takahashi N, Tabeta K, Aoki Y, Miyashita H, Miyauchi S, Miyazawa H, Nakajima T, Yamazaki K.
    • Journal Title

      PLos One in press

    • Peer Reviewed
  • [Journal Article] Porphyromonas gingivalis antigens and interleukin-6 stimulate the production of monocyte chemoattractant protein-1 via the up-regulation of early growth response-1 transcription in human coronary artery endothelial cells.2010

    • Author(s)
      Maekawa T, Takahashi N, Honda T, Yonezawa D, Miyashita H, Okui T, Tabeta K, Yamazaki K.
    • Journal Title

      J Vase Res. 47

      Pages: 346-354

    • Peer Reviewed
  • [Presentation] Apolipoprotein E欠損マウスにおけるPorphyromonas gingivalis長期感染後の血清脂質プロファイルの変化.2010

    • Author(s)
      多部田康一
    • Organizer
      第31回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-05
  • [Presentation] Porphyromonas gingivalis alters the serum lipid profile inmice.2010

    • Author(s)
      多部田康一
    • Organizer
      88^<th> General Session of the IADR
    • Place of Presentation
      Barcelona
    • Year and Date
      2010-07-17
  • [Presentation] 動脈硬化自然発症モデルマウスにおけるPorphyromonas gingivalis長期感染後の血清脂質プロファイルの変化.2010

    • Author(s)
      多部田康一
    • Organizer
      第132回日本歯科保存学会 2010年度春季学術大会
    • Place of Presentation
      熊本市
    • Year and Date
      2010-06-04
  • [Presentation] マウスPorphyromonas gingivalis口腔感染モデルにおける動脈硬化性変化の解析2010

    • Author(s)
      多部田康一
    • Organizer
      第2回口腔環境制御研究カテゴリー集会
    • Place of Presentation
      長崎市
    • Year and Date
      2010-02-10
  • [Remarks] ホームページ等

    • URL

      http://www.dent.niigata-u.ac.jp/yamazaki_labo/

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Published: 2012-01-26   Modified: 2014-03-17  

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