2010 Fiscal Year Final Research Report
Regulation of S1P in pathogenesis of periodontal disease
| Project/Area Number |
20592427
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YANAGITA Manabu Osaka University, 大学院・歯学研究科, 助教 (80379081)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Satoru 大阪大学, 歯学部附属病院, 講師 (40359849)
HASHIKAWA Tomoko 大阪大学, 大学院・歯学研究科, 助教 (00362682)
SHIMABUKURO Yoshio 大阪大学, 大学院・歯学研究科, 准教授 (50231361)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 歯周免疫機能学 / リゾリン脂質 / 歯肉線維芽細胞 |
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| Research Abstract |
In this study, we have investigated the effect of S1P on human gingival fibroblast (HGF). S1P upregulated to produce proinflammatory cytokine (IL-6 and IL-8) from HGF. Further, CD54 expression on HGF was induced by S1P in a dose-dependent manner. Antagonist of S1P2, one of the subsets of S1P receptor, reduced S1P-induced inflammatory cytokine production and CD54 expression on HGF. These findings indicate that S1P plays the important role as inflammatory mediator for establishment of periodontal disease.
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[Journal Article] Fibroblast growth factor-2 stimulates directed migration of periodontal ligament cells via PI3-K/akt signaling and CD44/hyaluronan interaction2011
Author(s)
Shimabukuro Y, Terashima H, Takedachi M, Maeda K, Nakamura T, Sawada K, Kobashi M, Awata T, Oohara H, Kawahara T, Iwayama T, Hashikawa T, Yanagita M, Yamada S, Murakami S.
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Journal Title
J.Cell.Physiol. 226
Pages: 809-821
Peer Reviewed
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