2010 Fiscal Year Final Research Report

Usefulness of LL37 as a multifunctional molecule for prevention of periodontal disease and periodontal tissue regeneration

Research Project

Project/Area Number	20592430
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Periodontal dentistry
Research Institution	Hiroshima University
Principal Investigator	SHIBA Hideki Hiroshima University, 病院, 講師 (60260668)
Co-Investigator(Kenkyū-buntansha)	FUJITA Tsuyoshi 広島大学, 病院, 助教 (80379883)
Co-Investigator(Renkei-kenkyūsha)	TAKEDA Katsuhiro 広島大学, 大学院・医歯薬学総合研究科, 助教 (10452591)
Project Period (FY)	2008 – 2010
Keywords	LL37 / 抗菌ペプチド / 歯周炎予防 / 歯周組織再生 / 血管新生
Research Abstract	LL37, which has antibacterial activity against cariogenic and periodontopathogenic bacteria abolished the increase in the factor involved in inflammation induced by periodontopathogenic bacteria. LL37 enhanced the production of the factor involved in angiogenesis. Furthermore, LL37 promoted the new bone formation in the rat experimentally created calvarial bone defect. Thus, in addition to antibacterial activity, LL37 is found to possess anti-inflammatory action, angiogenic activity and osteogenic activity, suggesting LL37 is possible to be useful for prevention of periodontal disease and periodontal tissue regeneration.