2010 Fiscal Year Final Research Report
Evaluation of the periodontal disease activity measuring the ability of dental plaque to activate innate immune system
| Project/Area Number |
20592431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
YOSHIMURA Atsutoshi Nagasaki University, 大学院・医歯薬学総合研究科, 准教授 (70253680)
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| Co-Investigator(Kenkyū-buntansha) |
HARA Yoshitaka 長崎大学, 大学院・医歯薬学総合研究科, 教授 (60159100)
NAKAYAMA Koji 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80150473)
KANEKO Takashi 長崎大学, 大学院・医歯薬学総合研究科, 助教 (10284697)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 歯周疾患活動性 / 歯肉縁上プラーク / 歯肉縁下プラーク / 自然免疫 / TLR2 / TLR4 |
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| Research Abstract |
Periodontal diseases are the inflammatory diseases caused by the bacteria in dental plaque. Since TLR2 and TLR4 play a central role in the recognition of bacterial products in periodontal tissue, we analyzed the ability of dental plaque to stimulate TLR2, 4. The ability of dental plaque to induce TLR4-mediated stimulation was positively associated with the clinical parameters at the sampled sites. The ability to induce TLR4-mediated stimulation was also associated with the levels of the cytokines produced by the peripheral blood mononuclear cells stimulated with the plaque. Endotoxins in the dental plaque possessed potent pro-inflammatory activities and measurement of the ability to induce TLR4-mediated stimulation would be useful for the evaluation of periodontal disease activity.
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[Journal Article] Transcriptional regulation of bone sialoprotein gene by Porphyromonas gingjvalis lipopolysaccharide2010
Author(s)
Xinyue Li, Naoko Kato, Masaru Mezawa, Zhengyang Li, Zhitao Wang, Li Yang, Yoko Sasaki, Takashi Kaneko, Hideki Takai, Atsutoshi Yoshimura, Yorimasa Ogata
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Journal Title
Journal of Cellular Biochemistry 110
Pages: 823-833
Peer Reviewed
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[Journal Article] グリチルレチン酸はLPS誘導性骨吸収を抑制する2008
Author(s)
中村弘隆, 鵜飼孝, 吉永泰周, 尾崎幸生, 金子高士, 白石千秋, 岸本真実, 小野山美穂, 阿部嘉裕, 安部達也, 吉村篤利, 原宜興
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Journal Title
日本歯科保存学雑誌 51
Pages: 323-330
Peer Reviewed
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