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2010 Fiscal Year Final Research Report

Biological responses that eliminate invasive bacteria in the periodontal cells

Research Project

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Project/Area Number 20592432
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionNagasaki University

Principal Investigator

KANEKO Takashi  Nagasaki University, 医歯薬学総合研究科, 助教 (10284697)

Co-Investigator(Kenkyū-buntansha) HARA Yoshitaka  長崎大学, 大学院・医歯薬学総合研究科, 教授 (60159100)
YOSHIMURA Atsutoshi  長崎大学, 大学院・医歯薬学総合研究科, 准教授 (70253680)
Project Period (FY) 2008 – 2010
Keywords歯周病原細菌 / ペプチドグリカン / NOD1 / NOD2 / サイトカイン
Research Abstract

Some of periodontal pathogens have an ability to invade gingival epithelial cells. This ability is thought as one of the mechanism to induce periodontal inflammation. In the present study, we focus on NOD proteins that have been shown to play an important role on detection and elimination of invasive bacteria, and investigate whether NODs proteins can recognize periodontal pathogens or not. As results, we find both NOD1- and NOD2-stimulatory activities are different by the species of periodontal pathogens.

  • Research Products

    (28 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) Presentation (17 results) Remarks (1 results)

  • [Journal Article] 歯周組織破壊に導く歯周病原細菌-宿主問相互作用の解明2011

    • Author(s)
      金子高士
    • Journal Title

      日歯周誌 53(1)

      Pages: 3-12

  • [Journal Article] NOD1 and NOD2 Mediate Sensing of Periodontal Pathogens.2010

    • Author(s)
      Okugawa T, Kaneko T, Yoshimura A, Silverman N, Hara Y.
    • Journal Title

      J Dent Res 89(2)

      Pages: 186-191

  • [Journal Article] Transcriptional regulation of bone sialoprotein gene by Porphyromonas gingivalis lipopolysaccharide.2010

    • Author(s)
      Li X, Kato N, Mezawa M, Li Z, Wang Z, Yang L, Sasaki Y, Kaneko T, Takai H, Yoshimura A, Ogata Y.
    • Journal Title

      J Cell Biochem 110(4)

      Pages: 823-833

  • [Journal Article] Activity of supragingival plaque to induce Toll-like receptor 4-mediated stimulation is associated with cytokine production by peripheral blood mononuclear cells.2009

    • Author(s)
      Yamaguchi R, Yoshimura A, Yoshioka H, Kaneko T, Hara Y.
    • Journal Title

      J Periodontol 80(3)

      Pages: 512-520

  • [Journal Article] Locally administered T cells from mice immunized with lipopolysaccharide (LPS) accelerate LPS-induced bone resorption.2009

    • Author(s)
      Ozaki Y, Ukai T, Yamaguchi M, Yokoyama M, Haro ER, Yoshimoto M, Kaneko T, Yoshinaga M, Nakamura H, Shiraishi C, Hara Y.
    • Journal Title

      Bone 44(6)

      Pages: 1169-1176

  • [Journal Article] Cyclosporin A and phenytoin modulate inflammatory responses.2009

    • Author(s)
      Suzuki AMM, Yoshimura A, Ozaki Y, Kaneko T, Hara Y.
    • Journal Title

      J Dent Res 88(12)

      Pages: 1131-1136

  • [Journal Article] Lack of Toll-like receptor 4 decreases lipopolysaccharide-induced bone resorption in C3H/HeJ mice in vivo.2008

    • Author(s)
      Nakamura H, Fukusaki Y, Yoshimura A, Shiraishi C, Kishimoto M, Kaneko T, Hara Y.
    • Journal Title

      Oral Microbiol Immunol 23(3)

      Pages: 190-195

  • [Journal Article] Analysis of the activity to induce TLR2- and TLR4-mediaed stimulation of supragingival plaque2008

    • Author(s)
      Yoshioka H, Yoshimura A, Kaneko T, Golenbock DT, Hara Y.
    • Journal Title

      J Periodontol 79(5)

      Pages: 920-928

  • [Journal Article] T cells are able to promote lipopolysaccharide-induced bone resorption in mice in the absence of B cells.2008

    • Author(s)
      Yamaguchi M, Ukai T, Kaneko T, Yoshinaga M, Yokoyama M, Ozaki Y, Hara Y.
    • Journal Title

      J Periodontal Res 43(5)

      Pages: 549-555

  • [Journal Article] グリチルレチン酸はLPS誘導性骨吸収を抑制する2008

    • Author(s)
      中村弘隆、鵜飼孝、吉永泰周、尾崎幸生、金子高士、白石千秋、岸本真実、小野山美穂、阿部嘉裕、安部達也、吉村篤利、原宜興
    • Journal Title

      日本歯科保存学雑誌 51(3)

      Pages: 323-330

  • [Presentation] ラット歯肉溝へのLPSおよび抗LPS IgGの交互滴下によりアタッチメントロスが誘導される2010

    • Author(s)
      藏本明子, 金子高士, 吉永泰周, 鵜飼孝, 白石千秋, 岸本真実, 横山美穂, 岸本隆明, 市村育久, 押野一志, 原宜興
    • Organizer
      第53回春季日本歯周病学会学術大会、盛岡市民文化ホールおよびいわて県民情報交流センター(アイーナ)
    • Year and Date
      20100514-20100515
  • [Presentation] NODによる歯周病原細菌の認識2009

    • Author(s)
      金子高士、吉村篤利、原宜興
    • Organizer
      第131回日本歯科保存学会2009年度秋季学術大会
    • Place of Presentation
      仙台市仙台国際センター
    • Year and Date
      20091029-20091030
  • [Presentation] P.gingivalis lipopolysaccharide regulates bone sialoproteins gene transcription2009

    • Author(s)
      Li X, Kato N, Kaneko T, Yoshimura A, Ogata Y
    • Organizer
      Europerio 6
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      20090604-20090606
  • [Presentation] 歯肉炎上プラークのTLR4刺激作用と末梢血単核球からのサイトカイン産生誘導能との関連2009

    • Author(s)
      吉村篤利、山口竜亮、吉岡英将、佐藤佳昌、金子高士、原宜興
    • Organizer
      第52回春季日本歯周病学会学術大会
    • Place of Presentation
      岡山市岡山コンベンションセンター
    • Year and Date
      20090515-20090516
  • [Presentation] Cyclosporin A and phenytoin differently modulate Toll-Like receptor-mediated responses in human gingival fibroblasts.2009

    • Author(s)
      Suzuki AMM, Yoshimura A, Kaneko T, Hara Y
    • Organizer
      The 9^<th> World Congress on Inflammation.
    • Place of Presentation
      Keio plaza hotel, Tokyo.
    • Year and Date
      20090515-20090516
  • [Presentation] 歯肉縁下プラークのToll-1ike receptor (TLR) 2およびTLR4刺激作用と歯周病臨床パラメーターの関連性について2008

    • Author(s)
      吉村篤利, 吉岡英将, 山口竜亮, 金子高士, 原宜興
    • Organizer
      第129回日本歯科保存学会2008年度秋季学術大会
    • Place of Presentation
      富山市富山国際会議場
    • Year and Date
      20081106-20081107
  • [Presentation] NOD mediates cytoplasmic sensing of periodontal pathogens.2008

    • Author(s)
      Kaneko T, Okugawa T, Yoshinaga M, Kishimoto M, Yoshimura A, Hara Y.
    • Organizer
      10^<th> Biannual IEIIS Meeting, International Endotoxin and Innate Immunity Society Edinburgh
    • Place of Presentation
      UK
    • Year and Date
      20080730-20080802
  • [Presentation] Identification of a cell surface component of Porphyromonas gingivalis that induces TLR2- and TLR4-independent activation of NF-kB in CHO cells.2008

    • Author(s)
      Kishimoto M, Yoshimura A, Naito M, Haruyama K, Kaneko T, Nakayama K, Hara Y.
    • Organizer
      10^<th> Biannual IEIIS Meeting, International Endotoxin and Innate Immunity Society Edinburgh
    • Place of Presentation
      UK
    • Year and Date
      20080730-20080802
  • [Presentation] Analysis of the activity to induce TLR2- and TLR4-mediated stimulation of supragingival and subgingival plaque.2008

    • Author(s)
      Yoshimura A, Yoshioka H, Suzuki AMM, Kishimoto M, Kaneko T, Golenbock DT, Hara Y.
    • Organizer
      10^<th> Biannual IEIIS Meeting, International Endotoxin and Innate Immunity Society Edinburgh
    • Place of Presentation
      UK
    • Year and Date
      20080730-20080802
  • [Presentation] Cyclosporin A modulates TLR-mediated responses in human gingival fibroblasts.2008

    • Author(s)
      Suzuki AMM, Yoshimura A, Kaneko T, Kishimoto M, Hara Y.
    • Organizer
      10^<th> Biannual IEIIS Meeting, International Endotoxin and Innate Immunity Society Edinburgh
    • Place of Presentation
      UK
    • Year and Date
      20080730-20080802
  • [Presentation] P.gingivalis lipopolysaccharide regulates bone sialoprotein gene transcription.2008

    • Author(s)
      Li X, Kato N, Maezawa M, Araki S, Kaneko T, Yoshimura A, Ogata Y.
    • Organizer
      日本歯科保存学会第128回春季学術大会
    • Place of Presentation
      新潟
    • Year and Date
      20080605-20080606
  • [Presentation] 歯周病原性細菌のNOD活性化能に関する研究2008

    • Author(s)
      奥川剛志、金子高士、吉村篤利、原宜興
    • Organizer
      第51回春季日本歯周病学会春季学術大会
    • Place of Presentation
      大宮
    • Year and Date
      20080424-20080425
  • [Presentation] Effects of Cyclosporin A on TLR-Mediated Responses of Gingival Fibroblasts.2008

    • Author(s)
      Suzuki AMM, Yoshimura A, Kaneko T, Hara Y.
    • Organizer
      第51回春季日本歯周病学会総会
    • Place of Presentation
      大宮
    • Year and Date
      20080424-20080425
  • [Presentation] NOD1 and NOD2 mediate cytoplasmic sensing of periodontal pathogens.

    • Author(s)
      Kaneko T, Okugawa T, Yoshimura A, Sato K, Hara Y.
  • [Presentation] Immune complex formed in rat gingival sulcus induces attachment loss.

    • Author(s)
      Kuramot A, Yoshinaga Y, Ukai T, Kaneko T, Shiraishi C, Yokoyama M, Sato T, Nagano F, Takamori Y, Hara Y.
  • [Presentation] An experimental model of periodontitis in LPS-Immunized rat.

    • Author(s)
      Yoshinaga Y, Kuramoto A, Kaneko T, Ukai T, Shiraishi C, Yoshinaga M, Sato T, Nagano F, Hara Y.
  • [Presentation] Cyclosporin A and phenytoin modulate inflammatory responses in gingival fibroblasts.

    • Author(s)
      Yoshimura A, Suzuki AMM, Y. Ozaki Y, Sato K, Kaneko T, Hara Y.
  • [Remarks] ホームページ等

    • URL

      http://www.de.nagasaki-u.ac.jp/education/dept_perio.html

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Published: 2012-01-26   Modified: 2016-04-21  

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