2010 Fiscal Year Final Research Report
BASIC RESEARCH FOR EFFECT OF OXIDISED GALECTIN-1 ON PERIODONTAL DISEASE THROUGH MACROPHAGE
| Project/Area Number |
20592438
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
HORIE Hidenori Kanagawa Dental College, 歯学部, 客員教授 (80046135)
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| Co-Investigator(Kenkyū-buntansha) |
SASAGURI Kenichi 神奈川歯科大, 歯学部, 講師 (10235286)
HAMADA Nobushiro 神奈川歯科大, 歯学部, 教授 (20247315)
NOZAKI Naohito 神奈川歯科大, 歯学部, 講師 (70222198)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ガレクチンー1 / マクロファージ / 歯周病 / LPS,サイトカイン / 炎症 / 予防 |
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| Research Abstract |
We established that galectin-1 mRNA is expressed in rat gingival tissues and also showed that galectin-1 mRNA significantly increased by the challenge with Porphyromonas gingivalis indicating galectin-1 may regulate oral inflammation. On the other hand, LPS (100 ng/ml) induced macrophages to upregulate mRNAs associated with a pro-inflammatory response, ie, interleukin-1β(IL-1β), interleukin -6 (IL-6), inducible nitric oxide synthase (iNOS). We show that oxidized galectin-1 application (10 ng/ml) to LPS-treated macrophages reduced the LPS-induced increase in pro-inflammatory mRNA expression. oxidized galectin-1 restricts the pro-inflammatory actions of LPS, and this protein could limit the negative effects of inflammation in periodontitis.
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[Journal Article] Galectin-1 promotes basal and kainate-induced proliferation of neural progenitors in the dentate gyrus of adult mouse hippocampus.2009
Author(s)
Kajitani K, Nomaru H, Ifuku M, Yutsudo N, Dan Y, Miura T, Tsuchimoto D, Sakumi K, Kadoya T, Horie H, Poirier F, Noda M, Nakabeppu Y
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Journal Title
Cell Death and Differentiation 16
Pages: 417-427
Peer Reviewed
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