Establishment of new periodontal basic treatment using antibiotics.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592439
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Tsurumi University
• Principal Investigator: ARAI Takashi Tsurumi University, 歯学部, 教授 (10014127)
• Co-Investigator(Kenkyū-buntansha): YASHIMA Akihiro 鶴見大学, 歯学部, 学部助手 (60460177)
• Project Period (FY): 2008 – 2010
• Keywords: 歯周基本治療 / 内服抗菌薬

Research Abstract

The aim of this study was to compare clinically and bacteriologically the effects of full-mouth SRP in conjunction with systemically administrated azithromycin (FM-SRP)at one time(test-1) or divided into several times(test-2) with conventional SRP(control). All clinical parameters for the two tests groups improved in comparison with the control. However, there were no significant difference between two test groups. The detection of the bacteria was not recognized until 24 weeks for two test groups. However, the re-detection of the bacteria was recognized from beyond 6 mm pocket after 36 weeks. The detection of the bacteria was recognized continuously after treatment for the control group. This result suggested that the FM-SRP shows similar effect for either of one time or several times.

Research Products

• [Journal Article] In vitro study of anti-suck-back ability by themselves on new high-speed air turbine handpieces. (2010)
  • Author(s): Ozawa T, Nakano M, Arai T
  • Journal Title: Dent Mater J.(Epub ahead of print) 19
  • Peer Reviewed
• [Journal Article] Microbicidal and cytotoxic effects of functional water in vitro. (2010)
  • Author(s): Gomi K, Makino T, Suzuki S, Hasegawa M, Maeda N, Arai T
  • Journal Title: Quintessence Int. 41 Pages: 166-172
  • Peer Reviewed
• [Journal Article] Cytodifferentiation activity of synthetic human enamel sheath proteinpeptides. (2010)
  • Author(s): Kakegawa A, Oida S, Gomi K, Nagano T, Yamakoshi Y, Fukui T, Kanazashi M, Arai T, Fukae M
  • Journal Title: J Periodont Res. 45 Pages: 643-649
  • Peer Reviewed
• [Journal Article] Effects of basic fibroblast growth factor on the development of the stem cell properties of human dental pulp cells. (2009)
  • Author(s): Morito A, Kida Y, Suzuki K, Inoue K, Kuroda N, Gomi K, Arai T, Sato T
  • Journal Title: Arch Histol Cytol. 72 Pages: 51-64
  • Peer Reviewed
• [Journal Article] One-stage full-mouth versus partial-mouth scaling and root planning during the effective half-life of systemically administered azithromycin. (2009)
  • Author(s): Yashima A, Gomi K, Maeda N, Arai T
  • Journal Title: J Periodontol. 80 Pages: 1406-1413
  • Peer Reviewed
• [Journal Article] Dental fiberscope with navigation system for endodontic treatment. (2008)
  • Author(s): Yamazaki Y, Ozawa T, Ogawa T, Shigeta Y, Ikawa T, Fukushima S, Arai T, Mishima A, Kobayashi K, Otake Y, Hattori A, Suzuki N
  • Journal Title: Stud Health Technol Inform. 132 Pages: 562-564
  • Peer Reviewed
• [Journal Article] Degradation of noncollagenous components by neutrophil elastase reduces the mechanical strength of rat periodontal ligament. (2008)
  • Author(s): Ujiie Y, Shimada A, Komatsu K, Gomi K, Oida S, Arai T, Fukae M
  • Journal Title: J Periodont Res. 43 Pages: 22-31
  • Peer Reviewed
• [Presentation] Effect of azithromycin to gingival and periodontal ligament fibroblasts. (2010)
  • Author(s): Gomi K, Yamaguchi T, Nagano T, Momoi Y, Arai T
  • Organizer: The 96^<th> Annual Meeting of American Academy of Periodontology in collaboration with the Japanese Society of Periodontology
  • Place of Presentation: Hawaii Convention Center, Honolulu, HI
  • Year and Date: 20101030-20101102
• [Presentation] アジスロマイシンを用いた歯周抗菌療法の多施設研究 (2010)
  • Author(s): 新田浩,五味一博,新井高,前田伸子,福田光男,野口俊英,野杁由一郎,恵比須繁之,島田靖子,吉江弘正
  • Organizer: 第53回日本歯周病学会秋季学術大会
  • Place of Presentation: サンポートホール高松
  • Year and Date: 2010-09-19
• [Presentation] インプラント周囲炎の診断・治療における細菌学的アプローチ (2009)
  • Author(s): 新井高
  • Organizer: 第39回日本口腔インプラント学会学術大会専門医教育講座
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 20090925-20090927
• [Presentation] The effects of full mouth SRP conjunction with Azithromycin for peri-implantitis. (2009)
  • Author(s): Makino T, Gomi K, Yashima A, Kawasaki F, Oshima T, Maeda N, Arai T
  • Organizer: The 6^<th> Annual Meeting of Asian Pacific Society of Periodontology
  • Place of Presentation: Cariton Hotel, Singapore
  • Year and Date: 20090829-20090830
• [Presentation] One-stage full- versus partial-mouth scaling and root planing under vali dity period of systemically administ rated azithromycin. (2009)
  • Author(s): Yashima A, Gomi K, Maeda N, Arai T
  • Organizer: EUROPERIO6(Stockholm International Fairs and Congress Centre)
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20090604-20090606
• [Presentation] 抗菌薬併用によるfull-mouth SRPにおける1回法vs.分割法の比較 (2009)
  • Author(s): 八島章博,五味一博,牧野智彦,近内理代,前田伸子,新井高
  • Organizer: 第52回日本歯周病学会春季学術大会
  • Place of Presentation: 岡山コンベンショナルセンター
  • Year and Date: 20090515-20090516
• [Presentation] インプラント周囲炎に対するfull-mouth SRPによる細菌叢の変化 (2009)
  • Author(s): 牧野智彦,大島朋子,五味一博,川崎文嗣,小川比佐誌,八島章博,前田伸子,新井高
  • Organizer: 第52回日本歯周病学会秋季学術大会
  • Place of Presentation: 宮崎観光ホテル
  • Year and Date: 2009-10-11
• [Presentation] full-mouth SRPと歯周外科処置を併用した侵襲性歯周炎の一症例 (2009)
  • Author(s): 八島章博,五味一博,新井高
  • Organizer: 第52回日本歯周病学会秋季学術大会
  • Place of Presentation: 宮崎観光ホテル
  • Year and Date: 2009-10-11
• [Presentation] インプラント周囲炎に対するfull-mouth disinfectionの細菌学的効果 (2008)
  • Author(s): 牧野智彦,小川比佐誌,川崎文嗣,大島朋子,五味一博,前田伸子,新井高
  • Organizer: 第51回日本歯周病学会秋季学術大会
  • Place of Presentation: 四日市市文化会館
  • Year and Date: 2008-10-19
• [Presentation] アジスロマイシンを用いた歯周抗菌療法の多施設研究-中間報告- (2008)
  • Author(s): 五味一博,新井高,前田伸子,野杁由一郎,恵比須繁之,小田茂,和泉雄一,新田浩,山本幸司,吉江弘正,福田光男,野口俊英
  • Organizer: 第51回日本歯周病学会秋季学術大会
  • Place of Presentation: 四日市市文化会館
  • Year and Date: 2008-10-19
• [Book] Periodontal Therapy Basic and Clinical Practices 3^<rd> Edition. (2009)
  • Author(s): 新井高,五味一博,八島章博, 他
  • Total Pages: 255
  • Publisher: 永末書店